Pathophys
Armadillo and people
What is the vector for leprosy?
Causes erythematous skin rash with diminished sensation
What is Tuberculoid leprosy?
Similar to action to sulfonamides
What is dapsone?
Used to determine tuberculoid vs lepromatous leprosy
What is a skin biopsy/stain?
2 ends of a spectrum of a disease with 5 subtypes
What is Tuberculoid leprosy (TT) and Lepromatous leprosy (LL)?
Large coalescent papules and nodules that give the face a deeply furrowed appearance (be specific)
What is leonine facies?
Binds beta subunit of DNA dependent RNA polymerase in prokaryotes
What is Rifampin?
What is India? --> 100k - 120k new cases annually = ~ 60% of the world's total
More indolent than M. tuberculosis
What is M. kansasii?
Causes sporotrichoids
What is M. marinum?
Leprosy prophylaxis
What is a single dose of rifampin?
Most common NTM to cause human infection
What is MAC?
Binds to Schwann cells, causing peripheral nerve damage & sensory loss
What is Phenolic Glycolipid-1 (PGL-1)?
Causes indolent pneumonia in middle-age to elderly patients with underlying lung disease
What is MAC?
Drug included in the treatment regimen for multibacillary leprosy but not paucibacillary leprosy
What is Clofazimine?
Positive lepromin skin test
What is a good Th1 response?
Cervical lymphadenitis not caused by M. tuberculosis
What is M. scrofulaceum?
3 Mycobacteria that can cause localized skin and soft tissue infections or more extensive systemic infection. (Need all for full points)
What are
M. abscessus,
M. chelonae,
and M. fortuitum?
Requires surgical debridement and multi-agent antibiotic therapy for several months
What is treatment for M. chelonae and M. fortuitum?
(NIV) Verse in the bible that has reference to Jesus healing a man with leprosy (STEP 1 relevant)
What is Matthew 8?