Meds 1
Meds 2
Meds 3
Age Related Changes
Beers Criteria
100

This juice inhibits CYP3A4 and can increase blood levels of many medications, including statins.

What is grapefruit juice?

100

This nutrient found in leafy green vegetables decreases the effectiveness of warfarin.

What is vitamin K?

100

An older adult takes levothyroxine every morning with milk. What happens?

What is decreased absorption of levothyroxine?

100

Older adults typically experience a decrease in this body component, which affects medication distribution.

What is total body water?

100

List four possible anticholinergic side effects.

What are:

  • Confusion
  • Memory impairment
  • Dry mouth
  • Blurred vision
  • Constipation
  • Urinary retention
  • Tachycardia
  • Falls?
200

An older adult taking lisinopril and spironolactone reports muscle weakness and palpitations after eating bananas daily. What complication do you suspect?

What is hyperkalemia?

200

A patient taking spironolactone asks if potassium salt substitutes are safe. Your response?

What is avoid potassium salt substitutes because they may cause hyperkalemia?

200

Which herbal supplement should be avoided with SSRIs because it may increase the risk of serotonin syndrome?

What is St. John's Wort?

200

Aging may decrease stomach acidity and slow gastrointestinal motility, affecting this pharmacokinetic process.

What is absorption?

200

Why are older adults more vulnerable to psychoactive medication adverse effects?

Age-related changes in absorption, distribution, excretion, and hepatic function increase serum drug concentrations.

1. Absorption changes

  • Older adults may have slower gastrointestinal motility and changes in stomach acidity.
  • This can alter how quickly medications are absorbed.
  • Psychoactive medications may have delayed or unpredictable effects.

2. Distribution changes

  • Older adults often have:
    • ↓ Total body water
    • ↓ Lean muscle mass
    • ↑ Body fat percentage
  • Fat-soluble medications (such as many psychoactive medications) may be stored longer in body fat.
  • This can lead to longer medication effects and increased risk of sedation.

3. Hepatic (liver) changes

  • The liver becomes less efficient with aging.
  • Medications may not be metabolized as quickly.
  • This causes medications to stay in the bloodstream longer and increases the risk of accumulation and toxicity.

4. Excretion changes

  • Kidney function commonly declines with age.
  • Medications may not be removed from the body as efficiently.
  • Drug levels can build up, increasing adverse effects.
300

This herbal supplement increases bleeding risk when taken with warfarin.

What is garlic?

300

Older adults are more sensitive to this pain medication class, increasing risk for adverse effects.

What are narcotic analgesics (opioids)?

300

The relationship between the body's biological rhythms and medication effects is called:

What is chronopharmacology?

300

The liver is responsible for this process that may become less efficient with aging.

What is medication metabolism?

300

This medication is considered a safer alternative for chronic anxiety because it is not addictive.

What is buspirone (BuSpar)?

400

Blood pressure commonly follows this pattern:

A. Decreases throughout the morning
B. Has a circadian surge in the morning
C. Remains identical all day
D. Peaks only during sleep  

What is a circadian surge in the morning?

400

Cardiac events such as myocardial infarction and stroke are more likely during: 

A. The middle of the night
B. The first hours after waking
C. Late afternoon only
D. After meals only

What are the first hours after waking (peak around 9–10 a.m.)?

400

Distribution of protein-bound medications can be affected by daily changes in:

What are albumin and glycoprotein levels?

400

An older adult starts a medication that can cause sedation. The nurse should implement which safety intervention?

What are fall precautions and monitoring for dizziness/unsteady gait?

400

Name three medication groups listed as potentially inappropriate medications.

What are:

  • Benzodiazepines
  • Tricyclic antidepressants
  • Anticholinergic medications
  • Digoxin
  • Sulfonylureas
  • Antispasmodics
  • Sliding scale insulin
  • Long-term proton pump inhibitors?
500

The nurse reviews medications for an older adult and finds sliding scale insulin. Why is this concerning?

What is sliding scale insulin is listed as a potentially inappropriate medication in older adults?

500

A patient receiving haloperidol develops sudden neck spasms, jaw tightening, and tongue movements. The nurse suspects:

A. Akathisia
B. Tardive dyskinesia
C. Acute dystonia
D. Depression

What is acute dystonia?

500

A patient takes warfarin and begins taking ibuprofen daily for arthritis pain. The nurse recognizes an increased risk for:

What is bleeding?
500

A nurse notices a sudden behavior change in a patient with dementia. Before giving an antipsychotic, the nurse should assess for:

What are reversible causes such as infection, dehydration, electrolyte imbalance, fever, or medication reactions?

500

The Beers Criteria evaluates medications based on these five areas, including medications inappropriate for all older adults and medications requiring changes with impaired renal function.

What are medication appropriateness, specific conditions, caution use, renal impairment, and harmful drug-drug interactions?