High Alert and High Risk Medication
Must-Know Drugs
Adverse Effects, Toxicity, & Antidotes
Contraindications
Patient Teaching & Medication Safety
100

This medication is considered high-alert because dosing errors can quickly cause hypoglycemia. 

What is insulin? 

100

Medications ending in "-pril" are primarily used to treat this condition. 

What is hypertension? 

100

Ringing in the ears is sign of toxicity caused by this medication. 

What is aspirin?

What is furosemide?

Either will be accepted. 

100

The nurse should question an order for cephalexin if the patient is allergic to this.

What are Penicillin? 

100

A patient using inhaled corticosteroids  should perform this action after administration. 

What is rinse the mouth? (prevents oral candidiasis)

200

The nurse should assess this lab value before administering IV heparin. 

What is the PTT?

200

This diuretic class causes potassium loss and often requires supplementation. 

What are loop diuretics. 

200

A patient receiving IV vancomycin develops flushing of the face, neck, and torso during infusion. Name this reaction. 

What is Red Man Syndrome? 

200

This medication should never be given to a child with a viral infection due to Reye's syndrome risk. 

What is aspirin? 

200

A patient taking beta blockers should monitor for this common side effect especially with changing positions. 

What is dizziness or orthostatic hypotension? 

300

This medication requires monitoring of the apical pulse for one full minute before administration.

What is digoxin?

300

This antibiotic class should be avoided in children due to effects on teeth. 

What are tetracyclines? (causes permanent tooth discoloration)

300

The nurse suspects digoxin toxicity when this electrolyte is low. 

What is potassium? (hypokalemia increases digoxin binding and toxicity risk)

300

These two types of drugs are contraindicated in patients with a history of bleeding.

What are anticoagulants and antiplatelets? 

300

A patient correctly demonstrates understanding of levothyroxine administration by stating they will take the medication at this time of day.

What is in the morning on an empty stomach? 

400

The antidote for opioid-induced respiratory depression is this medication. 

What is naloxone?

400
Beta blockers lower blood pressure primarily by affecting this organ system. 

What is the cardiovascular system? 

400

This medication reverses benzodiazepine overdose. 

What is flumazenil?

400

A patient with a decreased level of consciousness and absent gag reflex is at risk for this complication when oral medications are administered.

What is aspiration? 

400

A patient understands the side effects of long term opioid use if they institute this preventative measure.

What is a bowel regimen?

500

A patient receiving TPN that is unexpectedly discontinued due to lhe loss of IV access is at highest risk for this complication. 

What is hypoglycemia? 

500

This drug is the standard of care for treating acute angina pain. 

What is nitroglycerin? 

500

Bleeding gums and dark stools in a warfarin patient indicates this complication. 

What is excessive anticoagulation/bleeding?

500

A patient is prescribed enteric‑coated aspirin to be administered via a feeding tube. This is the nurse’s most appropriate action.

What is notify the provider the medication cannot be crushed? 

500

The patient understands patient teaching if they state this about long term prednisone use. 

What is do not discontinue abruptly?