Weird Hearts
Born This Weird
Pills and Potions
Hearts Gone Wild
Trial Files
100
Cardiac tumor associated with tuberous sclerosis
Rhabdomyoma
100
Cyanotic heart defect requiring PDA for systemic circulation.
HLHS
100
Drug causing blue-gray skin discoloration
Amiodarone
100
This cardiomyopathy is associated with DES gene mutations often features conduction disease, mid-myocardial fibrosis on MRI and may follow or precede skeletal myopathy
Dilated
100
Trial showing no ICD benefit in all cause mortaliy in non-ischemic cardiomyopathy
DANISH
200
Syndrome causing restrictive cardiomyopathy and hypereosinophilia
Loeffler
200
Defect showing scimitar sign on chest x-ray
PAPVR
200
Class III antiarrhythmic most selective for atrial tissue
Dofetilide
200
Genetic mutation linked to ARVC
PKP2
Mutations in PKP2 are found in approximately 45% of ARVC patients diagnosed with genetic ARVC. These mutations can lead to a reduced amount or altered structure of plakophilin-2, which is essential for the structure and communication between heart muscle cells
200
Trial showing no benefit of routine PCI in stable ischemic heart disease
ISCHEMIA
300
Right sided valve fibrosis without lung metastasis indicates presence of what tumor
Carcinoid
300
Atrial septal defect subtype associated with anomalous pulmonary veins
Sinus venosus
300
Of the beta blockers approved for heart failure, which is the least lipophilic
Bisoprolol
300
The inherited form of amyloidosis is caused by mutation in which gene
transthyretin gene
Leading to unstable TTR tetramers and deposition of amyloid fibrils
300
Trial supporting SGLT2 inhibitor use in HFpEF
EMPEROROR-Preserved
400
Congenital coronary anomaly causing infant myocardial infarction
ALCAP
A
400
Congenital defect associated with 'egg on a string' heart appearance
TGA
400
This non steroidal mineralocorticoid receptor antagonist was show in Fidelio-DKD and Figaro-DKD trials to reduce CV events in pts with CKD and DM2
Finerenone
400
What study showed that a cardiac myosin inhibitor improved symptoms and exercise capacity in patients obstructive HCM
Explorer-HCM trial
Lancet 2020
400
Trial showing bempedoic acid in statin-intolerant patients reduced CV events
Clear Outcomes (2023)
500
Endocarditis form HACEK organisms is more common after infection with which oral bacteria
Aggregatibacter
(formally Actinobacillus)
Hacek: peridontal diseas, slow growth
Aggregatibacter> Hemopophilus>cardiobacterium>Eikenala> Kingell
500
Syndrome featuring AV canal defect and hypocalcemia
DiGeorge
500
In the PARADIGM-HF trial Entresto demonstrated a 3% reduction in all-cause mortality compared to enalapril.
This corresponds to a NNT of how many patients to prevent one death
33
500
Infiltrative cardiomyopathy associated with Gaucher disease
Glycogen storage
500
Trial proving TAVI non-inferior to surgery in low-risk patients
PARTNER 3