OIT MLS Chem415 Final Review Part 3

Body Fluids

100

T/F  Decreases CSF glucose levels can indicate acute bacterial meningitis

True

200

What term is used to describe the collection method of pleural fluid?

Thoracentesis

300

Monosodium urate crystals are seen in the synovial fluid with what disease state?

Gout

400

What test can be performed to determine if the fluid coming from a patient's nose is sinus or spinal fluid?

Beta-transferrin

500

CSF total protein is considered to be what percentage of the total blood protein value?

0.5-1.0%

TDMs

100

Name 2 factors that influence drug concentrations and efficacy.

age, gender, genetics, diet, co-administered drugs, naturopathic agents

200

Weak bases are absorbed in the _____

intestine

300

Changes in concentration of this protein affects free vs bound drugs.

Albumin

400

If you have a result for a  total phenytoin of 11 ug/mL, what would an approximate value be for the free fraction?

1.1 ug/mL

10% free, 90% bound

500

This is the biochemical pathway responsible for a large portion of drug metabolism.

Hepatic mixed-function oxidase system (MFO)

Toxicology

100

What lipophilic drug is also known as "angel dust"

Phencyclidine (PCP)

200

What type of drugs are used to treat depression and mood disorders and are named for their chemical structure?

Tricyclic antidepressants (TCAs)

300

Positive drug screens for this type of substance has wide cross-reactivity with common OTC medications.

Amphetamines/Methamphetamines

400

If a person consumes alcohol at the same time as taking this drug, there is a higher risk of hepatic damage

Acetaminophen

500

This toxin is found in solid, liquid, and in solution. It binds to heme iron and high lactic levels are common.

Cyanide

Tumor Markers

100

This tumor marker is often elevated in patients with hepatocellular carcinoma and germ cell tumors.

alpha fetoprotein (AFP)

200

Which tumor marker has both free and bound forms that can be measured to help assist in risk stratification?

Prostate Specific Antigen (PSA)

300

Elevated levels of this tumor marker post treatment for ovarian cancer indicates a poor prognosis.

CA-125

400

This test is not actually cleared by the FDA as a tumor marker even though there is widespread use of it as one.

Human Chorionic Gonadotropin (hCG)

500

This tumor marker is primarily used for ovarian cancer and has improved specificity over CA-125

Human epididymis protein 4 (HE4)

Random

100

What CSF collection tube should chemistries be performed on?

Tube 1

200

What is the generic term for aspirin?

Acetylsalicylic acid

300

This potent inhibitor of many enzymes may cause basophilic stippling in RBCs.

Lead

400

Drugs that can easily cross cell membranes to enter cells and lipid compartments are considered _____

highly hydrophobic

500

This tumor marker is a modified Lewis blood group antigen.

Carbohydrate antigen 19-9 (CA 19-9)