Immunotherapy
The three most common side effects of immunotherapy.
What are fatigue, diarrhea and skin rash?
Approved in 1998 for treatment in breast cancer, it is the oldest anti-HER2 monoclonal antibody.
Trastuzumab
This medication is a reduced form of folic acid and is commonly used as a prophylactic rescue medication for high dose methotrexate.
What is leucovorin?
This chemotherapy agent was isolated from the needles of the Pacific Yew tree and belongs to the class of taxanes.
What is Paclitaxel?
TLS
What is Tumor Lysis Syndrome?
Two methods (scores) of evaluating PD-L1 expression in tumors
What are CPS (Combined Positivity Score) and TPS (Tumor Proportion Score)?
This monoclonal antibody targets the CD20 antigen on the surface of B-lymphocytes and is used in combination with chemotherapy in such regimens like R-CHOP to treat lymphomas
What is rituximab?
Filgrastim and it's longer acting form pegfilgrastim are used to stimulate this specific type of myeloid cell to help prevent infection in patients receiving chemotherapy.
What are neutrophils?
To prevent development of hemorrhagic cystitis, this prophylactic medication must be given concurrently with IFOSfamide infusions and sometimes with high doses of cyclophosphamide.
What is MESNA?
APL
What is Acute Promyelocytic Leukemia?
In patients experiencing Grade 2 or higher adverse events associated with immunotherapy in addition to holding therapy, this type of medication is used first line to elevate symptoms.
What are corticosteroids?
This EGFR-targeted monoclonal antibody is known to cause dermatological toxicities such as acneiform rash in up to 87% of patients and hypomagnesemia in up to 55% of patients.
What is Cetuximab?
This medication is used to quickly reduce excessively high methotrexate levels in patients developing renal toxicity.
What is glucarpidase?
This class of chemotherapy medications (which includes vincristine) has specific recommendations for IV use only, and fatal warning if given intrathecally.
What are the vinca alkaloids?
NSCLC
What is Non-Small Cell Lung Cancer?
Mechanism of action of Ipilimumab
What is CTLA-4 inhibition?
Premedications such as acetaminophen, H1 blockers and steroids are often given to prevent this side effect for many monoclonal antibodies.
What are infusion reactions?
The intracellular chelating agent is used as a cardioprotectant in patients receiving doxorubicin.
What is dexrazoxane?
Mechanism of action of Etoposide
What is topoisomerase II inhibition?
BSA
What is Body Surface Area?
The brand name of Atezolizumab + hyaluronidase
What is Tecentriq Hybreza?
The mechanism of action for Bevacizumab and Ramucirumab.
What is inhibition of vascular endothelial growth factor (VEGF)?
In patients with G6PD deficiency, this rescue agent enzyme for hyperuricemia can cause severe hemolytic reactions.
What is rasburicase?
Known as a vesicant, this ruby-colored chemotherapy agent has a recommended lifetime cumulative maximum dosing.
What is Doxorubicin?
MTX
What is methotrexate?