ONCOLYSTORY
The use of oncolytic viruses first stemmed from the observation that some cancer patients, who contracted an infectious disease, went into brief periods of _____.
What is remission?
VSV is short for this oncolytic virus.
What is Vesicular stomatitis virus?
The species name of HSV1.
What is simplexvirus?
This virus causes blisters and lesions in livestock leading to painful wounds. Ouch!
What is Vesicular stomatitis virus (VSV)?
In recent years, viruses have been _________ to further disable their pathogenicity, increase oncolytic potency, or enhance their specificity for cancer cells.
What is genetically modified?
The species name of VSV.
What is Rhabdovirus?
HSV1 nucleic acids are contained in this arrangement.
What is double stranded DNA (dsDNA)?
This virus causes lu-like symptoms, leading to possible paralysis.
What is Poliovirus?
The year that the first approved oncolytic virus is available for human treatment.
What is 2005?
These two outcomes occur after an injection of VSV into tumor cells.
What are
1) cell death
2) VSV amplification
This treatment has turned HSV1 safe by deleting a gene that blocks antigen presentation and the neurovirulence genes to prevent development of fever blisters.
What is T-VEC?
This virus commonly cause recurrent infection affecting the skin, mouth, lips, eyes, and genitals
What is Herpes simpex 1 (HSV1)?
The year that the first solid tumour was cured by chemotherapy.
What is 1958?
This specific engineering method makes VSV good at eradicating infection in healthy cells while maintaining replication in tumor cells.
What is deletion of MET-51 in matrix protein?
T-VEC uses these surface proteins to enter tumor cells.
What are nectins?
This virus may cause upper respiratory tract infections.
What is Adenovrius?
This was the ten year period in which extensive virotherapy research had begun.
What are the 1950's-1960's?
These two processes are induced by oncolysis of cancer cells which then target subsequent tumor cells.
What are
Oncolysis amplification via viral progeny.
ICD via antitumor immune responses triggered by the release of TAAs, DAMPs, and PAMPs.
This oncogenic and anti-viral pathway is disrupted by the treatment of T-VEC
What are protein kinase R (PKR) and type I interferon (IFN) pathways?
Both answers acceptable.
This infection is one in which a localized infection spreads from one area of the body to other organ systems.
What is a desseminated infection?