Diagnosis Plus
3 diseases associated with IVDU
What are hepatitis, HIV and infective endocarditis?
A test with high sensitivity and low specificity
What is an immunoassay? (also acceptable what is a presumptive test, what is a screening test)
times (in hours) when withdrawal from heroin and fentanyl begins
What are 6 and 12 hours?
Mechanisms of action of naltrexone, buprenorphine and methadone
What are antagonist, partial agonist and full agonist?
Medication used to reverse overdose
What is naloxone? (narcan)
4 risk factors for OUD
What are childhood trauma, genetic predisposition, early age of first use, untreated mental illness?
A test with near zero false positives?
What is gas chromatography? (also accepted what is a confirmatory or what is a definitive test)
7 common symptoms of opioid intoxication/overdose
30 points each
what are pinpoint pupils, decreased respiratory rate, decrease heart rate, nodding, pale clammy skin, limp muscles, unresponsiveness, blue lips/fingertips?
Need for increased amount of to get the same effect.
What is tolerance?
Data 2000 waiver
what is the Outdated restriction on buprenorphine prescribing?
Number of diagnostic criteria needed for diagnosis of severe, moderate and mild OUD?
What are >6, 4 or 5 and 2 or3?
3 ways to "pass" a urine drug test
What are adulterating, substituting and diluting?
The 11 opioid withdrawal symptoms assessed by the COWS scale.
(30 points each)
What are elevated pulse, chills, nausea/vomiting/diarrhea, tearing, goosebumps, restlessness, anxiety, , dilated pupils, muscle aches, yawning, and tremor
Substance that potentiates and worsens outcome of illicit opioid use and is known to cause serious skin lesions leading to abscess and amputation.
What is xylazine? (Tranc, a alpha 2 presynaptic agonist)
medications used to treat opioid use disorder (3)
what are methadone, buprenorphine and naltrexone?
Common psychiatric disorders that co-occur with OUD
hint: name 4 for full credit
What are anxiety, PTSD, depression and other substance use disorders?
commonly used Opioids that will be undetected on a screen for opiates?
4 for full credit
what are Oxycodone, buprenorphine, fentanyl and methadone?
Centrally mediated noradrenergic and cholinergic effects of fentanyl leading to rigidiy of diaphram, chest wall and upper airway muscles and death.
What is Chest Wall Rigidity?
Nucleus Accumbens-Ventral Tegmentum Area
What is the reward pathway?
a public health approach that focuses on mitigating the harmful consequences of drug use, including transmission of infectious disease and prevention of overdose, through provision of care that is intended to be free of stigma and centered on the needs of people who use drugs
What is Harm Reduction?
The 11 diagnostic criteria for substance use disorder
What are cravings, tolerance, withdrawal, inability to cut down, using more than intended, using despite physical/psychological harm, neglecting role responsibilities, excessive time spent getting/using/recovering substance, using despite social/personal problems, giving up hobbies/activities, use in hazardous situations?
Substances detected on a screen for opiates.
What are Morphine, 6-Monoacetylmorphine, and codeine and sometimes hydrocodone?
bonus: thebaine
2 Potential causes of dilated pupils in setting of opioid overdose?
What are mixed overdose and brain anoxia?
Neurotransmitters of Reward and Inhibition
what are Dopamine and GABA?
Relapse rate without medication treatment of oud?
What is 90%?