MME
Term for equivalent analgesia among opioids.
What is equinanalgesia?
First G-protein-biased μ-agonist FDA-approved for acute pain.
What is oliceridine (TRV-130)?
% of anesthesia providers developing SUD in career.
What is 0.65–1.6 percent?
Non-selective opioid antagonist reversing respiratory depression.
What is naloxone?
Major opioid receptor types.
What are μ (mu), κ (kappa), δ (delta), and OLR-1?
IV morphine is ~___ × more potent than oral morphine.
What is 3 times?
Mechanism giving oliceridine less respiratory depression.
What is reduced β-arrestin activation?
% of those cases involving opioids.
What is 40–70 percent?
Oral long-acting antagonist also used for alcohol dependence.
What is naltrexone?
The concept explaining prolonged effect after infusion.
What is context-sensitive half-time?
10 mg oxycodone × 4 / day = __ MME.
What is 60 MME?
This NaV1.8 blocker was recently approved by the FDA and has ongoing trials at UTMC.
What is suzetrigine (Journavx)?
Typical career stage when OUD develops.
What are the first five years of practice or residency?
This antagonist lasts ≈ 10.8 h and can prevent pruritus.
What is nalmefene?
Opioids act here in the spinal cord to modulate pain.
What is Rexed lamina II (substantia gelatinosa)?
2 mg hydromorphone q4h = __ MME.
What is 48 MME?
Opioid activating μ-receptors only in acidic tissue.
What is NFEPP?
Estimated mortality among affected providers.
What is 7–15 percent?
This quaternary antagonist treats opioid-induced constipation.
What is methylnaltrexone?
Highly lipophilic opioids cross this barrier rapidly.
What is the blood–brain barrier?
Morphine 30 mg BID + hydrocodone 5 mg q6h = __ MME.
What is 80 MME?
Mechanism of ACKR3 agonists like RTI-5152-12 (WW-12) in pain modulation
What is enhancing endogenous opioid tone by preventing endorphin scavenging at ACKR3 receptors?
One behavioral red flag for relapse.
What is renewed secrecy/isolation?
Effect of naloxone reversal on analgesia.
What is complete loss of analgesic effect?
Mechanism behind remifentanil-induced hyperalgesia.
What is NMDA receptor alteration?