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AJCC 8th Ed Staging
Pathology
Treatment & Guidelines
Complications & Outcomes
Miscellany
100

This is the only way a p16+ patient can be overall stage IV

Distant metastasis

100

This is a surrogate marker for HPV tumor status

What is p16?

100
These two treatment options have equivalent survival outcomes in early-stage oropharyngeal cancer

What are radiation and transoral surgery?

100

This is the most common long-term side effect of head and neck radiation therapy

What is xerostomia?
100

These are the HPV types that cause genital warts

What are HPV6 and 11?

200

In p16+ disease, bilateral nodes ≤6 cm fall under this N category

What is N2?
200

This HPV oncoprotein degrades p53

What is E6?

200
These are the indications for adjuvant chemotherapy
What are positive margins and extranodal extension?
200

Ligation of these two vessels reduced the risk of major bleeding after transoral robotic surgery

What are the lingual and facial arteries?

200

The lingual surface of the epiglottis is part of this major head and neck cancer site

What is the larynx?

300

This nodal categories (or greater) in HPV-negative OPC  result in Stage IVA+

What is N2?

300

This is the lining epithelium of the oropharynx

What is non-keratinized stratified squamous epithelium?

300

This is the number of weeks after surgery when radiation therapy should be initiated to avoid a survival decrement.

What is 6?

300
Radiation therapy dose to this muscle best predicts dysphagia

What is the superior pharyngeal constrictor?

300

This is the most sensitive test for recurrence of HPV(+) OPC

What is circulating tumor HPV DNA (NavDx)?

400

This is the most important prognostic risk factor that does not change AJCC stage

What is smoking pack-years (>10)?

400

These are the subsites of the oropharynx

What are palatine tonsillar complex, base of tongue, soft palate, and pharyngeal wall?

400

This is the most significant surgically-based treatment deintensification trial

What is ECOG 3311?

400

This anatomic variant is a contraindication to transoral robotic surgery

What is a retropharyngeal internal carotid artery?

400

This is the number of HPV types covered by the Gardasil vaccine

What is 9? HPV types 6, 11, 16, 18, 31, 33, 45, 52, and 58
500

This % of nuclear and cytoplastic p16 staining defines HPV-positive staging

What is 70%?
500

This is the gold standard test for transcriptionally active HPV

What is E6/E7 mRNA in situ hybridization?

500

This is the most common non-lung site of distant metastasis in HPV(+)OPC

Bone

500

This is the mechanism of action of the most common chemotherapy used in head and neck cancer

What is binding to DNA, forming cross-links to cause DNA damage?

500

This is the clinical stage of a 5 cm p16+ tumor with extension to the lingual surface of the epiglottis, depth of invasion 3 cm

What is stage T3?