Drugs and Classes
These are three classes of ototoxic drugs.
What are aminoglycosides, salicylate analgesics, antineoplastics, loop-inhibiting diuretics, and quinine.
These are 3 aspects of the audiologist's role in cochleotoxicity monitoring.
What is:
auditory monitoring, collaborative effort with oncology/others, implementing appropriate rehabilitation, coordinating in-service programs
These are routes of exposure to ototoxic chemicals (3).
___ children are at greater risk of ototoxic effects.
What are younger children?
This may be recommended for someone who has suffered vestibulotoxic effects.
What is Vestibular Rehabilitation Therapy?
Carbon monoxide and cyanide are part of this class of chemicals?
what are Chemical Asphyxiants?
Loss of response at __ consecutive frequencies where responses were previously obtained indicates a change.
"The overproduction of unstable and highly reactive forms of O2 that can cause cell damage" is the definition for which cellular process?
What is Oxidative stress?
Post-treatment follow up should occur at these intervals.
What is 3 months, 6 months, and 12 months?
This drug may be more vestibulotoxic than ototoxic.
What is Cisplatin?
This drug class is known to initiate drug interactions, increasing ototoxicity.
What are loop diuretics?
Speech, including word discrimination, immittance, and high frequencies should be assessed at this appointment.
What is the Baseline testing appointment.
What is the appointment following a change in hearing per monitoring.
Mid-frequency hearing loss is a common sign among this class of toxin?
What is chemical solvents?
This drug results in a characteristic 4k notch in hearing.
What is Quinine?
This is the main phenomenon we are looking to test for vestibulotoxicity monitoring.
What is the vestibule-ocular reflex?
A delay in wave 1 of the ABR and shifted inter-peak latencies are findings associated with which ototoxin?
What is lead?
These 3 tests should be completed following a change in thresholds.
What is speech audiometry, bone conduction, and immittance testing?
This cellular process is the predominant mechanism of cell death due to aminoglycoside exposure.
What is apoptosis?
This herbal supplement that may be used to treat cognitive impairment, GI function, dizziness and tinnitus may react with several medications, including SSRIs, Thiazide diuretics, and cyclosporin.
What is Gingo Blioba?
These two tests are preferred parts of the VNG for vestibulotoxicity monitoring.
Rotary chair
Sensory Organization Tests
Name three aminoglycosides.
What are:
Amikacin, Erythromycin, Gentamicin, kanamycin, neomycin, quinine, streptomycin, vancomycin, viomycin, salicylates, netilmicin, tobramycin
The following tests should be performed if a patient is unresponsive.
What is OAEs, ECochG, and ABR?
These drugs compete with OHCs for chloride anions at the bonding site, as their mechanism of ototoxicity.
What are analgesics?
These toxins, usually inhaled, are lipophilic, and can be found in the stria vascularis of the organ of corti. These chemicals are found in cleaning products, paints, and glues.
Bonus! This test may be used to screen vestibular function in young children or those unable/unwilling to participate in VNG.
What is the romberg position, tandem romberg, or single leg standing test?