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Regulation
Structure and Mutation
Analysis
Mode of Action
Research Papers
100
Low levels of P53 are normally maintained in the cell by this
What is protein degradation
100
These give rise to more than 90% of the identified P53 mutations
What are amino acid substitutions
100
Site of most common incidence of an ependymoma within an adult.
What is in the spinal cord
100
This protein phosphorylates p53 directly, and indirectly through CHK2, in response to a double-stranded DNA break
What is ATM
100
Name the 3 main roles of the p53 protein
What are Apoptosis, quiescence and cell cycle arrest
200
This ubiquitin ligase is responsible for the ubiquitination and subsequent breakdown of P53
What is the MDM2 protein
200
Amino acid substitutions in this P53 domain are frequently identified in cancer cells
What is the DNA-binding domain
200
Two methods used to identify base changes and short deletion mutations.
What is DNA sequencing and DGGE
200
This amino acid is phosphorylated on p53 in order to activate it
What is Serine
200
This substance promotes the ubiquitination of MDM-2, thereby increasing intracellular levels of P53
What is parthenolide
300
In addition to ubiquitination, MDM2 regulates P53 activity by this mechanism
What is blocking transcriptional activation
300
Phosphorylation of this site on P53 is required for induction of the apoptosis response
What is Ser-46
300
Site at which p53 single base mutation is most common in LFS.
What is codon 242 (A-->G)
300
Phosphorylation at Ser-20 on p53 blocks the action of this degradative protein
What is MDM2
300
Wild-type p53 can be therapeutically delivered to cells using this vector
What is adenovirus