Weeks 1-3: Pharm
Which pharmacokinetic parameter represents the highest drug concentration achieved after administration and is often associated with the onset of therapeutic effects?
Peak concentration (Cmax)
Rationale: The peak concentrations after intermittent doses at steady state will be equal to the peak concentration after the first dose multiplied by the accumulation factor
This vitamin deficiency is commonly found in patients with heavy alcohol abuse and frequently associated with nystagmus, ataxia and paresthesia
What is Thiamine Deficiency?
This is the primary mechanism underlying Factor V Leiden mutation?
Factor V protein is resistant to inactivation by activated protein C
If treatment is pursued, this is the most common treatment option for molluscum contagiosum
What is cryotherapy
This is the preferred oral antibiotic to treat methicillin-sensitive staph aureus skin and soft tissue infection
What is Cephalexin
This is the branch of pharmacology that deals with the undesirable effects of chemicals on living systems is defined by which term?
What is Toxicology
This is considered the first line agent to treat an uncomplicated dermatophyte infection of the skin
What is Terbinafine cream
This is a type of bleeding disorder characterized by deficiency in Clotting Factor VII
This is the first (and foremost) intervention to manage a drug eruption
Discontinue the offending drug
This is why Rifampin is contraindicated to treat TB in patients who are also taking antiretroviral therapy
Rifampin induces CYP 450 enzymes which leads to increased metabolism (clearing) of HIV antivirals
This is the term that is defined by: "the effects of the body on drugs, for example, absorption, metabolism, and excretion"
What is Pharmacokinetics
This micronutrient deficiency can be manifested with alopecia, delayed sexual maturation, muscle wasting and dermatitis.
What is Zinc deficiency?
This triad of laboratory findings is commonly seen after administering chemotherapy
What is Pancytopenia
This is the primary treatment for lichen planus
What are topical corticosteroids
This is a common side effect of non-nucleoside reverse transcriptase inhibitors (NNRTIs) in HIV treatment?
Hepatotoxicity
This is the role that special carrier molecules play in drug transport across membranes
They bring about movement by active transport or facilitated diffusion
This is the primary habitat (location) of Staphylococcus epidermidis in the human body?
What is the skin
This type of hematologic malignancy classically presents with leukocytosis and has the presence of the Philadelphia Chromosome
What is CML? (Chronic Myeloid Leukemia)
This is a skin condition that is commonly associated with hormonal changes
What is melasma
This is the mechanism of action of erythropoietic stimulating agents (ESAs)
What is the stimulation of erythropoiesis by binding to erythropoietin receptors on erythroid progenitor cells in the bone marrow.
This is the primary determinant of drug permeation across biological membranes?
What is Lipid Diffusion
This is the classic, first-line regimen for uncomplicated tuberculosis
What is Isoniazid, rifampin, pyrazinamide and ethambutol
Multiple myeloma is characterized by the abnormal proliferation of these types of cell produced by the bone marrow.
What are plasma cells?
This is the the primary purpose of administering intravenous fluids in the initial management of severe burns
What is to replace fluid loss and maintain tissue perfusion
This is the pharmacokinetic principle that represents the total systemic exposure to a drug over time
What is the Area under the concentration-time curve (AUC)