Indications
What is the pharmacologic classification of pantoprazole?
A. H2 receptor antagonist
B. Proton pump inhibitor (PPI)
C. Anticholinergic
D. Antacid
B. Proton pump inhibitor (PPI)
Pantoprazole is a ___.
What is a proton pump inhibitor
List one common side effect and how would a nurse assess it?
Headache, abdominal pain, facial puffiness, edema, chest pain, gas, nausea, vomiting, hyperglycemia
What effect does pantoprazole have on stomach pH?
It increases pH, making the stomach less acidic.
Muscle cramps, seizures or irregular heartbeat are indicative of what?
What is low Mg levels in the body. Healthcare professional should be notified
What enzyme does pantoprazole inhibit to reduce stomach acid production?
A. Amylase
B. Pepsin
C. (H+, K+)-ATPase
D. Protease
C. (H+, K+)-ATPase
Pantoprazole binds to this on the parietal cell surface of the stomach
What is a proton pump (H+/K+ ATPase enzyme)
What are some serious stomach conditions caused by pantoprazole and how would you assess for them?
Stomach cramps, bloated feeling, watery and severe diarrhea which may also be bloody). Stomach conditions can be assessed by asking about bowel habits, looking for signs of dehydration, and performing a GI focused assessment
Which herbal supplement can reduce pantoprazole’s effectiveness?
St. John’s Wort
Why? It increases the metabolism of pantoprazole, reducing its effectiveness.
You should not do this with your Pantoprazole treatment, even if you start feeling better.
What is to stop taking Pantoprazole early
Pantoprazole is most commonly used to treat which condition characterized by stomach acid flowing back into the esophagus?
A. Gastric ulcer
B. GERD (Gastroesophageal reflux disease)
C. IBS (Irritable bowel syndrome)
D. Crohn’s disease
B. GERD
These 2 isoenzymes discussed today are involved in the metabolism of Pantoprazole.
What is CYP2C19 and CYP3A4
One common side effect is hyperglycemia. What are the signs and symptoms of hyperglycemia?
Urinating large amounts, excessive thirst, feeling tired, frequent hunger, dry mouth, weight loss, blurred vision.
What form of pantoprazole should be used in an NG tube?
The granule form, as prescribed by a physician.
A patient taking pantoprazole says that the 40 mg tablet is too large to swallow. What is the most appropriate advice the nurse should give?
A. Crush the tablet and take it with water
B. Split the tablet in half and take each half separately C. Ask the healthcare provider to prescribe two 20 mg tablets
What is C = ask the healthcare provider to prescribe two 20mg tablets
How does pantoprazole help with erosive esophagitis?
A. It coats the esophageal lining
B. It increases mucus production
C. It neutralizes acid instantly
D. It reduces stomach acid to promote healing
D. It reduces stomach acid to promote healing
After oral administration, pantoprazole must first leave this organ before it can be absorbed due to its delayed-release, enteric-coated formulation.
What is the stomach
List 2 serious sides effects that I mentioned
Blistering, peeling, or bleeding skin; sores on the lips, nose, mouth, or genitals; swollen glands; shortness of breath; fever; or flu-like symptom
How and when should pantoprazole be taken?
It should be taken as a whole tablet, 30–60 minutes before a meal, preferably before breakfast.
Why should a patient notify their healthcare provider of their history of bone fractures or osteoporosis?
Pantoprazole use can lead to bone fractures
What rare condition, involving excess stomach acid secretion, is pantoprazole used to treat?
A. Cushing’s syndrome
B. Zollinger-Ellison syndrome
C. Addison’s disease
D. Graves’ disease
B. Zollinger-Ellison syndrome
Approximately 71% of pantoprazole’s inactive metabolites are excreted through this route.
What is urine
List 3 common side effects
Headache, abdominal pain, facial puffiness, edema, chest pain, gas, nausea, vomiting, hyperglycemia
Which medication increases the risk of bleeding when taken with pantoprazole?
Warfarin
A patient on Pantoprazole who has developed diarrhea should do this
What is to continue Pantoprazole use and consult with their healthcare provider before taking an antidiarrheal