Causes
What is Idiopathic
It has an unknown cause
This symptom can occur at rest or while moving
Tremors!
Parkinson's Disease is known to worsen over time. This type of disease is known as what?
progressive (neuro-degenerative)
What are some environmental factors to Parkinson's Disease?
Pesticide exposure, head injuries and living or working in a farmland/country setting
Bradykinesia is a common symptom of Parkinson's Disease. What does this mean?
Slowness of movement (inability to perform rapid, alternating movements).
Parkinson's Disease is more commonly found in males. True or False
True
What are dopamine agonists
They bind to dopaminergic post-synaptic receptors in the brain have similar effects to levodopa
What is the main cause of the motor symptoms?
The death of dopamine-generating cells in the substantia nigra
Individuals with Parkinson's disease often have complications with walking. What is this called?
Gait!
Current Drug Therapy cures Parkinson's Disease.True or False?
False
We inhibit monoamine oxidase-B. What are we?
MAO-B inhibitors
What is the pathology of Parkinson's Disease
The accumulation of alpha-synuclein into inclusions called Lewy bodies in the neurons
What occurs at later stages of Parkinson's
Dementia and Depression
Dopamine agonists work by activating dopamine receptors in the striatum. True or False?
True
The most commonly used surgical procedure in PD
List some of the genetic mutations in people with Parkinson's
SNCA, LRRK2 and GBA
"TRAP" stands for a way to remember the symptoms of Parkinson's Disease. Any guesses as to what each letter means?
TREMOR (involuntary trembling of the limbs), RIGIDITY (stiffness of the muscles), AKINESIA/BRADYKINESIA (lack of movement or slowness in initiating and maintaining movement), POSTURAL instability (bending or flexion of the body, associated with difficulty in balance and disturbances in gait)
This part of the brain is a collection of nerve cells that lie deep within the brain, and help with coordination and muscle movements
Basal Ganglia
Often required in the last stages, when most treatment options are ineffective
Palliative Care