DDx for uveal melanoma
A magnocellular nevus of the retina is also known by this name.
The main study describing prognostic factors for uveal melanoma and treatment options based on size (basal diameter).
What is the COMS?
BONUS +100: what does this stand for?
The most common globe-sparing method to treat uveal melanoma.
What is radioactive plaque?
BONUS +100: Most common plaque?
BONUS +200: Second most common plaque?
BONUS +100 for any others
The HLA alleles associated with Birdshot and Behcet.
What are A-29 and B-51?
A patient with bear tracks should be referred for evaluation of this condition.
What is colon cancer/Gardner syndrome?
This technique can be used to estimate the size of more anterior/ciliary body melanocytic tumors when high frequency UBM is not available.
What is transillumination?
An older treatment for uveal melanoma that is still often used for very small melanomas or as adjuvant therapy with plaques.
What is TTT?
BONUS +200: what does it stand for?
What is map biopsy?
A dramatic peripheral, hemorrhagic retinal condition occurring in elderly pts with suprachoroidal or subretinal bleeding and lipid exudation, thought to be analogous to AMD.
What is PEHCR?
BONUS +300: what does the acronym stand for?
The 5 classic clinical risk factors for growth/malignant transformation of choroidal nevi.
BONUS +300: for each additional cited risk factor you can name
What is:
Thickness > 2 mm, Fluid under retina, Sx, Orange pigment, Margin of tumor touching ONH
("To Find Small Ocular Melanomas")
BONUS: larger size at presentation, absence of drusen or degenerative RPE changes, homogenous low internal reflectively on US, hot spots on fluoroscein angiography
A particular complication that may occur following radiation of large ocular melanomas which may lead to enucleation despite tumor death.
The type of adhesions present in type 1 Peters anomaly.
What is iridocorneal?
BONUS+ 300: what type of adhesions in type 2 pts?
The diagnosis of a new inferonasal dark mass you see on POD1 after placement of an Ahmed tube shunt.
What is vortex vein varix?
The chance that a pigmented choroidal lesion </= 1 mm thick is a uveal melanoma.
BONUS +400: chance if > 3 mm thick?
What is < 1 %?
What is > 20%?
What is charged-particle radiation?
Three ways to make a contact lens fit more tightly.
What are: increase sagittal depth, increase diameter, or steepen the base curve (AKA decrease ROC)
The most likely visually-significant complication of a yellow-orange juxtapapillary choroidal tumor (classically in a young woman) with very high internal reflectivity on B-scan.
What is subretinal neovascularization (due to choroidal osteoma)?
What incidence of metastatic disease associated with uveal melanoma at time diagnosis, 5 years, 10 years and 25 years after initial treatment?
+500 for each correct answer within 5%, -500 for each wrong answer more than 10% off.
What is < 2%, 25%, 34%, and 50%.
Name at least two genetic factors associated with a high probability of metastatic disease associated with uveal melanoma.
When treating patients with river blindness caused by this nematode (+500 pts), you must beware of a fatal reaction (+500 pts) to this drug (+500 pts) if pts happen to be coinfected with this other nematode (+500 points).
1st guess on nematodes free, -500 pts for subsequent incorrect guesses.
What is oncocerca volvulus, fatal encephalitic reaction, ivermectin, and loa loa?