Motor disorders/stroke
Hyperkinesia is a key symptom of...
Huntingtons
Precurser for aspartate is
Oxaloacetate
Major inhibitory NT in the brain
GABA
Dopamine is derived from
tyrosine
Serotonin is an ___ mediates its own release
autocoid
Disorder of progressive degeneration of lower motor neurons leads to loss of initiation and control of voluntary movement
ALS
excess glutamate-mediated excitation and depolarization in foci area is correlated to
Seizures or epilepsy
What drugs are positive allosteric modulaters on the GABAa receptor
Benzodiazepines, barbiturates, ethanol, steroids
Effect of the dopamine transporter
transport terminates signaling
5-HT is a precursor for this hormone that is released from the pineal gland
melatonin
On the non-verbal pain scale what score indicates severe pain
7-10
Group 1 glutamate receptors are _____(excitatory/inhibitory) and _____tropic
Excitatory and metabo
Rate limiting step in the synthesis of GABA
Decarboxylation of glutamate using GAD
D1 and D5 dopamine receptors are excitatory and drive _____ (hyperpolarization/depolarization)
depolarization
5-HT1 receptors activated in the ____ and ____ regulate sedation and sleep
Cortex and hypothalamus
Drug that is now regulated by law that produces parkinsons disease
Meperidine
What two things MUST happen for an NMDA receptor to become active
Glutamate bind to open receptor AND Mg2+ unbinds
Which GABA receptor is metabotropic
GABAb
Apomorphine is a D2 ____ (agonist/antagonist) and has an _____ effect
Agonist, excitatory
Via the caudal raphe pathway an agonist to the 5-HT3 receptor will cause
vomiting or nausea
Riluzole a treatment for ALS, its mechanism blocks what neurotransmitter
Glutamate
What happens when you apply an agonist to kainate receptors
fast, excitatory response
Glycine antagonist, deadly poision
Strychnine
This pathway regulates the reward involves in drug abuse
mesocorticolimbic pathway/ A10
LSD is an agonist for what 5-HT receptors
1A, 2, 5+6