Anemia’s
impaired oxygen transport due to lack of hemoglobin, tissue hypoxia, microcytic hypochromia anemia.
What is the pathology of Iron Deficiency Anemia.
Reduction of all cell lines including RBC, WBC, and Platelets.
Pathology of Aplastic Anemia.
compound defect in both platelet function and coagulation pathway.
Von Willebrand Disease
Too little hemoglobin
Hypochromic
RBC Values for Males and Females
M: 4.2-5.4 million per microliter
F: 3.6-5.0 million per microliter
Decreased synthesis of either alpha and or beta chains of the hemoglobin caused by deletion of the gene; results in hypochromic, microcytic, anemia w hemolysis.
Pathology of Thalassemias?
A common etiology of this disease is kidney disease with a high erythropoietin production.
Etiology of Polycythemia.
X linked recessive disease mainly affecting males, is associated with factor VIII.
Hemophilia A
normal RBC
normocytic
Hemoglobin Values for Male and Females
M: 14-17.4 grams per 100 mL
F: 12-16 grams per 100 mL
This is prevalent in African American Men, it is a recessive inherited disease.
Sickle Cell Disease
Leading cause of death in children.
Leukemia
Deficiency in this can result in decreased DNA Synthesis and decreased maturation of RBC.
Folic Acid.
Regular amount of hemoglobin
normochromic
Hematocrit Values for Males and Females
M: 42-52%
F: 36-48%
This Anemia can be caused by gastrectomies, surgery/tumors involving ileum, and malabsorption syndromes.
Etiology of Pernicious Anemia.
There is a 70% cure rate for this disease, it is a painless disease.
Hodgkin’ Disease.
A child under 2 years of age drinks cowmilk, what are they in risk of?
Iron Deficiency Anemia.
small RBC
microcytic
Reticulocyte value
1-1.5% of total RBC, can be up to 10% if a lot of RBCs are being made.
This unique sign/symptom is ataxia and paresthesias due to spinal cord demyelinization.
Sign and Symptom of Pernicious Anemia.
Having less than 100,000 platelets is called
Thrombocytopenia
When valine replaces glutamic acid this results in...
Sickle Cell Disease.
these cells came from bone marrow, precursor stem cells.
hemocytoblast
Neutrophils Value & when does it rise
60-65% of total WBC & # rises in infectious disease