I've got you under my skin
Did I do it to myself?
You are contagious
It's all in your head
I am my worst enemy
Feeling Rejected
Hodge Podge
100

The pathognomonic lesion of acne

comedone

100

This mechanism, proposed to induce autoimmunity, is a result of viral or bacterial protein epitopes similar to the host's self-components.

What is 'molecular mimicry'?

100

Extensive vesicular and pruritic rash and the lesions are in various stages of healing

What is chickenpox?

100

Wet or dry, drusen are usually there

Macular degeneration

100

Antinuclear (ANA) and  Anti-Smith (Sm)

What are autoantibodies for SLE (Lupus)?

100

It is when you give an organ to someone and they don't accept it!

What is transplant rejection?

100

A patient with chronic Rheumatoid arthritis can have this type of extracellular deposits of fibrillar proteins (be specific)

What is AA (amyloid-associated) amyloidosis?

200
Benign lesions with crater-like morphology

Keratoacanthoma

200

This autoimmune disease affects 0.2% of the population and is caused by an autoimmune attack on the pancreas.

What is Insulin-dependent diabetes mellitus (IDDM), or What is Type 1 diabetes mellitus?

200

This lesion is composed of the following cells

What is a caseating granuloma?

200

This cancer, characterized by keratin pearls, makes up 95% of head and neck cancers.

Squamous cell carcinoma

200

This is the most sensitive autoantibody for SLE

What is ANA (anti-nuclear antibody)?

200
A tissue graft from a donor of the same species as the recipient but not genetically identical


What is an allograft?

200

A 55-year-old Japanese woman has amyloidosis associated with rheumatoid arthritis. She presents with nephrotic syndrome and renal biopsy specimens are obtained. This renal section is stained with the following stain.


What is congo red stain?

300

Sometimes a signal of occult malignancy when many suddenly appear, but more often occur as "barnacles on the ship of life" as greasy, dark plaques.

seborrheic keratosis

300

This disease presents as an overlap of SLE, Systemic sclerosis, and Polymyositis


What is Mixed connective tissue disease?

300

Maine will be testing newborn for this virus

What is Cytomegalovirus (CMV)?

300

In some parts of Africa, where EBV is endemic, this is the most frequent childhood cancer.

nasopharyngeal carcinoma

300

Check for this autoantibody for drug-induced lupus

What is anti-histone antibody?

300

A tissue graft or organ transplant from a donor of a different species from the recipient.

What is Xenograft?

300

It is also called Vitamin C

What is ascorbic acid?

400

This skin cancer precursor is famous for its cutaneous horns and association with sun exposure.

Actinic keratosis

400

The patient with the following signs and symptoms has this disease.

What is Lupus (SLE)?

400

Painful,erythematous and burning rash in a dermatomal pattern

What are shingles (herpes zoster)?


400

Because of this, yellow soft cotton wool spots are formed in the retina  

What is ischemia?

400

This autoantibody is most specific for lupus nephritis

What is dsDNA?

400

These are responsible for hyperacute graft rejection

What is the role of pre-formed antibodies?

400

This important component of the connective tissue is defective in this sailor

What is collagen?

500

Characterized by palisading cells surrounding basophilic nests, it's also the most common eyelid malignancy.

Basal cell carcinoma

500

A 24-year-old female presents to her doctor with increased joint pain over the last six months. On further questioning, she admits to noticing ankle swelling at the end of each day and having a rash that appears across her cheeks and nose after she has been working outside. A complete blood count reveals a platelet count of 90,000/mm3 (150,000 to 400,000/mm3) but otherwise is within normal limits. These are the most specific antibodies for her condition.

What are  Anti-dsDNA or anti-Smith antibodies? 

500

It is a pathology test showing multinucleated giant cell and intranuclear inclusions in HSV and VZV infection

What is the Tzanck smear?

500

Seen especially in immunocompromised patients, it is a fluffy, hyperkeratotic thickening on the lateral border of the tongue.

hairy leukoplakia

500

Anti-U1-RNP (ribonucleoprotein)

What are autoantibodies for Mixed connective tissue disease?

500

Manifests as interstitial fibrosis and gradual narrowing of graft blood vessels (graft arteriosclerosis)


What is chronic graft rejection?

500

This pathological change is visible on a liver biopsy from this child

What is microvesicular steatosis?

600
This pattern of destruction is visible along the dermoepidermal junction in lichen planus.

Zigzag (or sawtooth)

600

The occurrence of this type of lymphoma is the most serious complication of Sjogren's syndrome (SS).

What is Non-Hodgkin's lymphoma (NHL)?

600

Congenital infection with this virus causes Microcephaly and Periventricular Calcifications 

What is CMV or Cytomegalovirus?

600

Surf's up! The fancy name for this fleshy, vascular mass that grows over the cornea.

pterygium

600

Anti-DNA topoisomerase antibodies

What autoantibody is specific for Systemic Sclerosis?

600

It occurs a few minutes after the transplant when the antigens are completely unmatched

What is hyperacute graft rejection?

600

The deficiency of this vitamin caused keratinized patches over her conjunctiva (figure)



What is vitamin A deficiency?

700

These nonacantholytic blisters occur when antibodies target hemidesmosomes

bullous pemphigoid

700


What is the mechanism of lupus flares when exposed to sunlight?

700

The biopsy specimen shows multiple enlarged cells with basophilic intranuclear inclusions and a surrounding halo

What are CMV inclusion bodies?

What are CMV-infected cells?

700

This substance is commonly produced by sympathetic paragangliomas, but rarely by the parasympathetic types.

Catecholamines

700

This autoantibody is associated with a higher likelihood of CREST syndrome

What is Anti centromere antibody?

700

It occurs when the pre-formed antibodies bind to antigens on the graft endothelium and activate the complement and clotting systems leading to endothelial injury, thrombus formation, and ischemic necrosis of the graft

What is hyperacute graft rejection?

700


What is scurvy?

800

Seeding of blood by malignant T cells can lead to this diffuse erythema and scaling of the entire body surface.

Sezary syndrome

800

Order this specific antibody to diagnose this patient

What is anti-DNA topoisomerase I (anti-Scl 70) antibody?

800

It is this lesion shown here in a pulmonary resection specimen with a rounded calcified nodule  

What is a Ghon focus of Tuberculosis?

What is a caseating granuloma?


800

This developmental cyst usually presents around the crown of an unerupted tooth in the mandible.

Dentigerous cyst

800

Antibodies against these two antigens can be detected in as many as 90% of patients with Sjogren syndrome.

What are SS-A (Ro) and SS-B (La)?

800

A 37-year-old man presents with abdominal pain, diarrhea, vomiting, and jaundice. His medical history was significant for acute lymphoblastic leukemia diagnosed 1 year ago. Following ablative chemotherapy, he received a bone marrow allograft from a related donor.

On physical examination,  a  maculopapular rash is present  over  his  neck,  shoulders,  palms,  and  soles. Laboratory studies show elevated AST and ALT. He most likely has this disease.

What is Graft vs Host Disease?

800

These are the radiodense lines in the metaphysis and epiphysis of the children in the following scenario


What are the lead lines?

900

Whereas HLA-B locus alleles are strongly associated with psoriatic arthritis, this other class of HLA locus alleles are more strongly associated with cutaneous psoriasis.

HLA-C

900

In this syndrome, the patient presents with the following features. 

What is CREST syndrome?

  • C is for Calcium deposits in the body tissues
  • R stands for Raynaud’s Phenomenon
  • E is for Esophageal reflux, commonly referred to as heartburn
  • S is for Sclerodactyly or thick skin on the fingers
  • T is for Telangiectasias which are enlarged blood vessels that appear as red spots on the face and other areas
900

This is what the liver biopsy shows.


What is microvesicular steatosis? 

900

Cervical lymphoepithelial cysts along the sternocleidomastoid muscle most commonly arise from this branchial arch.

What is the second branchial arch?

900

This is what happened to her

What is drug-induced SLE? (Phenytoin)

900

It is one of the most common opportunistic viral infections that affect the outcome of solid organ transplantation.

What is cytomegalovirus?

900

The deficiency of a particular vitamin causes these two conditions called ---- and ------

What are Xerophthalmia and Bitot spots? (Vitamin A deficiency)

1000

The disease you associate with these granules, and hepatosplenomegaly, signs of bone marrow invasion, and a condition mimicking seborrheic dermatitis.

Langerhans cell histiocytosis (Letterer-Siwe Disease)

1000

What is Mixed connective tissue disease?

1000

Male age 52

Tissue: Lung

This HIV-positive patient developed progressive weight loss, fever and cough. He was found to have multiple small opacities in the lungs on X-ray. He was started on the appropriate treatment but his general condition deteriorated and he died 2 weeks after admission. The section is taken from one of the lungs.

https://www.virtualpathology.leeds.ac.uk/ug/week.php?number=5&case_id=243

What is miliary Tuberculosis?

1000

Associated with cigarette smoking, this parotid gland lesion contains oncocytic cells on a lymphoid stroma.

Warthin tumor (Papillary cystadenoma lymphomatosum)

1000

Mothers with these autoantibodies should be counseled regarding the risk of NLE (neonatal lupus erythematosus)

What are SSA/Ro and/or SSA/La antobodies?

1000

In this type of transplant rejection, we see the following changes

Tubulointerstitial fibrosis

What is chronic rejection?

1000

This type of amyloidosis is seen in this particular disease

What is Multiple Myeloma?