Clinical Manifestations
This symptom involves difficulty recalling recent events or conversations and can be an early indicator of the disease.
What is Memory loss?
This protein, when abnormally folded and builds up outside of neurons, forms plaques that disrupt cell communication in the cerebral cortex.
What is amyloid-beta?
This type of imaging test shows areas of the brain where nutrients are not being properly used for energy.
What is Fluorodeoxyglucose PET imaging?
This class of drugs is commonly prescribed to temporarily improve memory and cognitive function by increasing the levels of acetylcholine in the brain.
What are Cholinesterase inhibitors?
In this year, at the 37th Meeting of South-West German Psychiatrists, this disease was first described through a case study of a 50-year-old woman who presented with paranoia, progressive sleep disturbance, and memory disturbance.
What is 1906?
Personality changes involving a gradual decline in emotional regulation, leading to mood swings and irritability, especially in the advanced stages of the condition.
What is behavioral and mental confusion?
The gradual loss of neurons in this region, which is important for memory formation, leads to early issues with memory.
What is the hippocampus?
This type of exam is utilized to measure “instrumental activities of daily living”, and those who require higher concentration indicate a decline is cognitive ability.
What is the Functional Activities Questionnaire?
This NMDA receptor antagonist is used to help regulate glutamate activity in the brain, potentially improving cognition and memory in patients with severe cognitive decline.
What is Memantine?
It is estimated that there are currently ___ Americans who provide unpaid care for those suffering from this illness and others similar.
What is 11 million?
A common manifestation in the later stages of this disorder includes getting lost in familiar settings, often due to a breakdown in spatial navigation abilities.
What is spatial disorientation?
The intracellular accumulation of hyperphosphorylated forms of this structural protein leads to neurofibrillary tangles, contributing to cell death.
What is tau protein?
During this type of exam, a physician will test reflexes, coordination, muscle tone and strength, eye movement, speech, and sensation.
What is a neurological exam?
This therapy involves structured mental exercises and group discussions to maintain cognitive function and delay the progression of memory loss.
What is Cognitive stimulation therapy?
It is stated that in the United States, this disease is the ___ leading cause of death among people age 65 and older in 2021.
What is the 5th?
A cognitive decline involves the gradual loss of the ability to perform essential daily tasks, such as bathing, dressing, and preparing meals.
What is the decline in activities of daily living (ADL)?
Chronic inflammation of this organ, involving microglia, accelerates neuronal damage and synaptic loss over time.
What is the brain?
This type of test is utilized to detect disease-related biomarkers. These biomarkers include: amyloid-beta peptides, tau protein, and neurofilament light chain.
What is a blood test?
This approach to treatment involves utilizing non-pharmacological interventions, such as modifying the environment and establishing routines, to reduce behavioral symptoms.
What are behavioral interventions?
It is stated that Black Americans are ___ as likely to have this illness than Non-Hispanic White Americans.
What is twice?
Individuals with this condition often experience this behavior, frequently repeating questions or telling the same stories.
What is Perseveration?
Reduced levels of this neurotransmitter, responsible for memory and learning, result from degeneration of the basal forebrain cholinergic neurons.
What is acetylcholine?
This test is completed with MRI or CT and can give physicians a structural image of an individual’s brain.
What is brain imaging?
The primary goal of pharmacological treatments for this condition is to stabilize or slow down the decline in cognition and function, rather than reversing the disease process.
What is symptom management?
About 1 in __ women are affected by this disease, while 1 in 10 men are affected.
What is five?