Innate immunity
What is the main cell type that phagocytoses?
Macrophages
What cell releases antibodies?
T cells have ________ that recognize and bind to antigen presented on MHC?
T-cell receptors
This is what binds to the target of interest and how we identify it on the machine
Antibody bound to a fluorophore
This type of treatment releases the brakes on the immune system
Immune checkpoint blockade
What is the main cell type for allergic reactions that produces histamine?
Basophils
What is the one type of T cell that functions to stop inflammation?
Regulatory T cells
This is where T cells develop and mature
Thymus
In order to increase the fluorescence during compensation, we increase the ________ for that laser
Voltage
This is when cancer cells spread to other parts of the body
Metastasis
What is the process of releasing granules?
Degranulation
What is the difference between plasma and memory B cells?
Plasma B cells continue to make antibodies while memory B cells need re-stimulation
Which MHC class do CD4 vs CD8 T cells recognize?
MHC-I : CD8 T cells
MHC-II : CD4 T cells
How do you determine the size of a cell?
Forward and side scatter
Cancer cells acquire this so that the immune system can no longer recognize it
Mutations
What are all 3 antigen presenting cell types?
Dendritic cells, macrophages, and B cells
These proteins are key to make diverse BCRs
RAG proteins
Immune cell interactions occur mostly in these organs/sites
Secondary lymphoid structures ie spleen and lymph nodes
Immunologists do this to determine least and still effective amount of antibody to use for flow cytometry
Titration
Repeated vaccinations rely on which cell type for protection if exposed to the pathogen
Memory B cells
What is the term for the interaction between a DC and a T cell?
Immunological synapse
What signals and attracts other immune cells to a site of infection?
Chemokines
Antibodies can bind to a pathogen, which signals to the immune system to start this cascade to destroy it
Complement cascade
Immunologists make these controls in order to perform compensation to fix spillover
Single stain controls
This type of engineered therapy is very effective for blood cancers
CAR T cell therapy