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This ossification process involves mesenchymal cells directly differentiating into osteoblasts without a cartilage template
Intramembranous ossification
In this process, a cartilage model is replaced by bone over time
Endochondral Ossification
This disease, caused by defective collagen formation, leads to brittle bones and can affect both ossification processes
Osteogenesis Imperfecta
This type of ossification is responsible for forming the flat bones of the skull, mandible, and clavicle.
Intramembranous ossification
The first step in endochondral ossification is the formation of this structure around the diaphysis
Bone Collar
A disorder caused by defective endochondral ossification due to mutations in the FGFR3 gene
Achondroplasia
Osteoblasts secrete this substance, which later mineralizes to form bone matrix in intramembranous ossification
Osteoid
During endochondral ossification, this region remains as cartilage at the end of long bones, allowing for continued growth until adulthood
Epiphyseal Plate
Defects in intramembranous ossification can result in delayed closure of these fibrous joints in the skull
Fontanelles (soft spots in infant skull)
A child presents with bowing of the legs and widened growth plates on X-ray. Deficiency of this vitamin is responsible for defective mineralization during endochondral ossification
Vitamin D (Regulates calcium and phosphate homeostasis)
A rare disorder caused by defective osteoclast function results in excessive bone density, brittle bones, and narrowing of cranial nerve foramina. What is the name of this condition?
What Is Osteopetrosis?