Apolipoproteins
Lipoprotein that has ApoB48, CII, and ApoE
What is chylomicron?
lipoprotein that is a scavenger protein
what is HDL
In what tissues lipoprotein lipase is found
What is adipocytes, muscle, and heart
rate limiting step of cholesterol synthesis
what is HMG coA reductase
Which apolipoprotein is required to activate LCAT
What is Apo A1?
Located on HDL
lipoprotein that is a transport protein
what is VLDL
enzyme that esterifies free fatty acid to cholesterol to make cholesteryl esters
what is ACAT
HMG CoA reductase
which apolipoprotein is required for secretion from enterocytes
What is ApoB48
lipoprotein mostly cholesterol and only ApoB100
what is LDL?
enzyme that esterify cholesterol from tissues to pack as much cholesterol into HDL as possible
LCAT
name two things cholesterol can be used for
- lipid membrane
- steroidgenesis
- vitamin D
- bile salts
which apolipoprotein is required for uptake of remnant chylomicrons
what is apo E
Lipoprotein that has a protein which exchanges it’s own cholesterol esters for TGs in VLDLs, IDLs and LDLs
what is HDL?
the protein is CETP
SREB protein is responsible for transcription of gene that upregulates this
what is LDL receptors
name of macrophages filled with cholesterol
what are foam cells
found in atherosclerotic plaque
draw out the cholesterol synthesis pathway starting with acetyl CoA. whoever is done first gets these points!
[in the liver] 2 acetyl coA --(thiolase)--> acetoacetyl coA + acetyl coA --(HMG CoA synthase)--> HMG CoA --(HMG CoA Reductase)--> mevalonate -->> squalene -->> cholesterol