Toxidromes
Patient with hypertension, tachycardia, agitation, dilated pupils, diaphoresis
Sympathomimetic Toxidrome
This medication will briefly reverse an opioid overdose
What is Naloxone?
N-acetylcysteine is used to treat toxicity and prevent liver failure from overdosage of this medication
What is acetaminophen
Patient with hypertension, tachycardia, agitation, dilated pupils, urinary retention, dry skin
What is anticholinergic toxicity
The antidote for beta blocker overdose.
What is glucagon?
Optimal to administer within 60 minutes of toxin ingestion.
What is activated charcoal or gastric lavage?
Patient with bradycardia or tachycardia, small pupils, incontinence, diarrhea, hypersalivation, bronchorrhea
What is cholinergic toxicity?
The antidote for calcium channel blocker overdose.
What is Calcium/insulin/dextrose?
Patient appears intoxicated, has a fruity smelling breath. Labs show non-anion gap acidosis but elevated serum osmolar gap. Patient ingested this
What is Isopropyl Alcohol
Patient presents with pinpoint pupils, shallow respirations, bradycardia, and improves with Naloxone. UDS is negative for all drugs. Name the culprit medication.
What is clonidine?
Patient intentionally overdoses on her migraine medication Amitryptiline, and presents with ALOC, hypotension and QRS widening on EKG
What is Sodium Bicarbonate
Useful with medications with long half-lives, sustained-release dosage form, enteric-coated formulation, toxic substances not adsorbed by activated charcoal.
What is whole bowel irrigation?
Two drug classes that would exhibit anticholinergic toxidrome symptoms.
What are TCA, antihistamines, antipsychotics, cyclobenzaprine, atropine?
A patient presents in status epilepticus and standard therapy does not work. Grandmother is taking an antibiotic medication after having a positive PPD 2 weeks ago
What is Vitamin B6 or pyridoxime (Isoniazid toxicity)
This flowering plant that grows well in late summer which produces classic Anticholinergic Toxidrome
What is Jimson Weed