Evidence Rating
Down's Syndrome
Down's Syndrome 2
Random
100

Level of Evidence: can reassure otherwise health younger than 70 year old with acute cough, normal vitals and normal chest exam that CAP is highly unlikely 

C

100

Up to what age should a Down's syndrome patient have an Individuals Family Service Plan?

3 years old

100

Recommended referral to consider between age 3-4?

Sleep study to rule out OSA

100

Acute bronchitis duration, patients should be counseled it could last...

2 to 3 weeks

200

Level of Evidence: Delayed abx prescription decreased abx use without affecting patient satisfaction. 

A

200

Name 5 Common Physical Characteristics with Down's Syndrome

Arched Palate

Brachycepahly

Ear abnormalities

Epicanthal Folds

Michrocephaly

Macroglossia

Upward slant to eyes

Widened gap between first and second toes 

200

After age 1 month, what do all patients need to be recommended in their diet?

Adequate iron intake as patients with Downs are more likely to have iron deficiency and macrocytosis 

200

What treatments for Tpe 2 DM have improve outcomes in older adults?

GLP1 and SGLT2 have improved patient outcomes in older adults with differing effects on cardiovascular and renal outcomes (Level 1a evidence)

300

Level of Evidence: SNRI, such as duloxetine and TCA can be used to treat chronic pelvic pain.

B

300

What is the most common medical problem for patients with Down's Syndrome?

60-80% have vision and eye disease 

50-79% have OSA

50-70% get otitis media 

300

What vaccines are HIGHLY recommended for all Down's patients due to high risk of hospitalization early in life?

RSV

FLU

Prevnar 

300

High flow nasal cannula in treatment of bronchiolitis does what for outcomes compared to low flow oxygen?

A. Reduces hospital stay

B. No effect on treatment escalation 

C. Increased the risk for adverse outcomes

Reduces hospital stay

400

Level of Evidence: NSAIDS and gabapentin can be considered in the treatment of chronic pelvic pain

B
400

Recommended blood tests from 1 month to 1 year?

TSH at 6 and 12 months 

CBC/diff AND either ferritin/CRP OR iron/TIBC 

400

What tests are recommended in a patient with Down's syndrome at ALL annual visits?

Hearing, TSH, CBC

400

What is a risk factor for progression of Barrett esophagus to esophageal adenocarcinoma or high-grade dysplasia?

Increasing length of Barrett Esophagus (1 point per cm)

500

Level of Evidence: Pacifiers can reduce pain associated with common medical procedures

A

500

How often should an individualized family plan for Downs patients be re-evaluated for current needs?

every 6 months

500

What test has the lowest false positive rate of all Down's screening antepartum?

Cell-free DNA

500

What medication is an effective treatment for adults with severe postpartum depression with a strength of recommendation level A?

Zuranolone (GABA A receptor modulator)