Anemia
A 4 year old girl presents with the following labs:
- iron is low
- TIBC is high
- Tsat is low - ferritin is low
What is the most likely diagnosis
iron deficiency anemia
A 4 year old girl presents with the following:
- fever, apthous ulcers, cervical lymphadenitis, and occasional rectal and vaginal ulcers.
- these symptoms occur about every 21 dayas
What is the most likely diagnosis?
cyclic neutropenia
What is the most common childhood malignancy?
ALL
What is the most common primary malignant tumor of the kidney in childhood?
Wilms tumor
What major side effect do you worry about with doxorubicin?
cardiomyopathy
structural or functional abnormality of the cytoskeletal proteins: spectrin, ankyrin and more
complications include cholelithiasis due to biliary stones and aplastic crisis from parvovisu
positive osmotic fragility test confirms the diagnosis
What congenital hereditary anemia has these characteristics
hereditary spherocytosis
Autosomal recessive inherited white blood cell disorder that presents at a young age with severe bacterial infections and ANC of < 200/ul.
Kostmann Syndrome ( severe congential neutropenia)
A boy has a suspicious lymph node. What are the cells called in Hodgkin Lymphoma?
Reed Sternberg Cells
What is the most common malignancy in infants?
Neuroblastoma
What side effect do you worry about with Vincristine?
neuropathy
What is one of the first symptoms in children with sickle cell disease?
dactylitis
Autosomal recessive disorder that presents with: neutropenia, exocrine pancreatic insufficiency, diarrhea, short stature, metaphyseal dysostoses, recurrent infections and FTT
Schwachman-diamond syndrome
A 3 year old child presents with painful limping, and CBC shows pancytopenia. What is the most likely diagnosis?
ALL
What is the most common primary bone tumor in children?
osteosarcoma
what is the treatment for an acute stroke in a patient with sickle cell disease?
Exchange transfusion
What is the leading cause of death in children and adults with sickle cell disease?
ACS ( Acute Chest Syndrome)
A 4 year old girl presents with the following: 2 weeks ago she had a viral URI and now she has acute onset bloody nose, petechial rash, labs showing normal hbg, plt counts of 4K, and peripheral smear is normal except for lack of platelets. What is the most likely diagnosis?
ITP
What is the most common type of Lymphoma to occur in children?
Non-Hodgkin Lymphoma
A 20 month old presents with ataxia, myoclonic jerking, and random eye movements. What is the most likely underlying diagnosis?
Neuroblastoma, patient has opsomyoclonas
A child getting chemotherapy for ALL, presents with acute onset epigastric pain that radiates to the back and is found to have elevated lipase level. What is the most likely chemotherapy agent that caused this side effect?
L -asparaginase
A 4 year old child whose family is vegan presents with pallor and fatigue. CBC shows a megaloblastic anemia. What is the most likely diagnosis?
B12 deficiency
Autosomal recessive, presents with neonatal bleeding. Thrombocytopenia is severe, but other cell lines are normal. There are decreased or absent megakaryocytes in the BM. The newborn as absent radii, but normal thumbs. What syndrome is this?
TAR (thrombocytopenia-absent radius) syndrome
What is the fastest growing cancer known to man that presents either in the jaw or the abdomen as a fast growing mass?
Burkitt's Lymphoma
A 15 yar old male presents with fever, weight loss, rib pain, primary lytic lesion with "onion skinning" on the diaphysis of the right femur on x-ray. What is the most likely diagnosis?
Ewing Sarcoma
A 5 year old blonde boy with eczema gets recurrent bacterial infections. What is the most likely underlying disease?
Wiskott aldrich syndrome