Potpourri
Patients with lung cancer, pre-existing lung conditions, and a smoking history may be at a higher risk for this immunotherapy side effect
What is pneumonitis?
Prognosis as well as treatment selection is highly dependent on these two factors in patients with breast cancer
What are tumor stage and receptor type?
This androgen deprivation therapy is the only orally available agent
What is relugolix?
This medication is indicated for the treatment of steroid-refractory colitis and carries a risk of tuberculosis activation
What is infliximab?
This LAG-3 inhibitor is only approved in combination with nivolumab
What is relatlimab?
This screening method is recommended in patients who are at least 50 years old and have at least a 20 pack-year smoking history
What is low-dose CT scan (annually)?
This multigene test is used to determine the risk of recurrence in patients with HR-positive, HER2-negative breast cancer
What is Oncotype DX?
This rare side effect was reported in clinical trials with all second-generation anti-androgens, except for darolutamide
What is seizure?
Tamoxifen is a major substrate of this CYP enzyme, often leading to drug interactions with other medications like antidepressants
What is CYP2D6?
This treatment was the first T-cell therapy approved for a solid tumor cancer
What is lifileucel?
This drug class is indicated as adjuvant endocrine therapy in post-menopausal patients with early-stage breast cancer
What are aromatase inhibitors?
Cardiac monitoring is recommended at this frequency during treatment in patients receiving trastuzumab
What is every 3 months?
This management strategy is preferred in older patients with localized, low-risk prostate cancer and a shorter life-expectancy
What is observation?
These two drug classes should not be used simultaneously in patients with breast cancer due to the risk of cardiotoxicity
What are anthracyclines and HER2-targeted agents?
This rule is used to assess moles or skin lesions for signs of skin cancer
What is the ABCDE rule?
This targeted therapy is indicated as maintenance therapy in patients with BRCA-positive stage II-IV ovarian cancer
What is olaparib?
Patients with this receptor subtype of metastatic breast cancer do not require upfront chemotherapy
What is HR-positive/HER2-negative?
This phenomenon can initially occur in patients receiving a GnRH agonist and may be prevented with concomitant antiandrogen therapy
What is tumor flare?
This anti-androgen therapy used in the treatment of prostate cancer must be taken on an empty stomach, as taking with food can increase absorption
What is abiraterone?
Tumor staging in melanoma is dependent on these two factors
What are Breslow thickness (tumor thickness) and ulceration status?
Chemotherapy is not indicated as first-line therapy in patients with metastatic colon cancer who have this biomarker
What is dMMR or MSI-H?
This antibody-drug conjugate is preferred second-line therapy in patients with metastatic HER2-positive breast cancer
What is fam-trastuzumab deruxtecan?
This treatment regimen is reserved for patients with metastatic castration-sensitive prostate cancer who are young and fit, and have a high volume of disease
What is ADT + docetaxel + darolutamide or abiraterone (AKA triplet therapy)?
This multi-kinase inhibitor targeting VEGF, used in the treatment of colon cancer, must be taken following a low-fat meal
What is regorafenib?
This BRAF inhibitor can cause hemolytic anemia in patients with G6PD deficiency
What is dabrafenib?