Antifungals
Can be prescribed instead of Amphotericin B due to decreased toxicity
What is Ketozonazole?
Acts on cells in the bone marrow to increases production of neutrophils
What is Neupogen?
These should be avoided while taking Rapamune
What are high-fat foods?
Infusion Reaction, Hypokalemia, Nephrotoxic, Hematological Effects
What are AEs of Amphotericin B?
2-4 Hrs
How long should Amphotericin B be infused for?
Usually taken with greasy foods to increase absorption
What is Griseofluvin?
Pre-op is the only TU for this drug
What is Oprelvekin?
Used to prevent organ rejection of those receiving liver, kidney, and heart transplants
What is Tacrolimus?
Drugs that increase gastric pH and inhibits
What are drug interactions of Itraconazole?
What do all patients prescribed Amphotericin B experience to some degree?
H/H, LFTs, Electrolytes, Renal labs
What are the 4 labs you must monitor when giving Amphotericin B?
Used to treat chronic neutropenia
What is Neupogen?
Contraindicated for pregnancies
What is Imuran?
Bone pain and leukocytosis
What are AEs of Neuopgen?
Prevention of organ rejection in transplant, Treatment of autoimmune disorders
What are indications for immunosuppressants?
Patients diagnosed with HF are contraindications of this drug
What is Itraconazole?
HgB level, CBC, BUN, uric acid, creatinine, K, pH, Iron
What are labs to monitor when prescribing Erythropoietin?
Can decrease Tacrolimus levels
What is Rifampin?
Bone marrow suppression leading to neutropenia or thrombocytopenia
What are AEs of Imuran?
Given to patients undergoing myelosuppressive chemo
What is Oprelvekin?
Nausea, vomiting, headache, pain in back, legs, abdomen
What are AEs of Intrathecal Amphotericin B?
R/T chemo, chronic renal failure, and pre-op
What are anemic therapeutic uses for Erythropoietin?
Must watch for hypokalemia in this drug, and hyperkalemia in this drug
What is Rapamune/Tacrolimus?
What are AEs of Cyclosporine? (ik this is not real jeopardy style)
Nephrotoxicity, Infection, Hepatotoxicity, Hypertension, Gingival Hyperplasia, Tremor, Hirsutism, Hyperkalemia, Leukopenia, avoid in pregnancy if possible
What is the TOXIC acronym for Amphotericin B? (yes, ik this is not real style)
Toxic to kidneys, Observe H/H/elect/renal, Xamine multi organ failure, Interaction, Cardiac failure