Pharmacokinetics
What the body does to the drug.
What is Pharmacokinetics?
Can be defined as the study of substances that interact with living systems through chemical processes.
What is Pharmacology?
Sequence of 3 nucleotides that codes for an amino acid or stop signal
What is a codon?
maximal effect produced by a drug
What is Efficacy?
- Absorption
- Distribution
- Metabolism
- Excretion
What are the 4 Principles of Pharmacokinetics?
Often defined as the science of substances used to prevent, diagnose, and treat disease.
What is Medical Pharmacology?
The process used to determine the two alleles a person has at a particular DNA location
What is Genotyping?
Is the study of a drug's molecular, biochemical, and physiologic effects or actions.
What is Pharmacodynamics?
Changing a compound into something more usable by the body
What is Biotransformation?
Is the branch of pharmacology that deals with the undesirable effects of chemicals on living systems
What is Toxicology?
1. Transcription
2. Splicing
3. Translation
What is Gene Expression?
Physiological mediators
Hormones, neurotransmitters, inflammatory mediators
What are Receptors?
greatest effect on bioavailability
What is the First-Pass Effect?
The use of drugs to prevent, diagnose, or treat signs, symptoms, and disease process
What is Drug Therapy?
Study of the relationship between variations in a large collection of genes and variability in drug disposition, response, and toxicity
What is Pharmacogenomics?
response to a drug which is noxious & unintended
What is Adverse Drug Reactions?
1) route of administration
2) solubility of drug administered
3) conditions at site of absorption
4) degree of ionization of the drug
5) bioavailability
What are the 5 Factors that impact the degree of drug absorption?
1- their effect on a particular body system
2- their therapeutic use
3- their chemical characteristics
What is Drug Classification?
1. Down's syndrome
2. Klinefelter Syndrome
3. Turner Syndrome
What are diseases with alterations in chromosome number?
•G protein-coupled
•Enzyme-linked transmembrane
•Intracellular (nuclear)
•Transmembrane ion channels
What are 4 Receptor Types?