Black Box 1
This may occur when ACE inhibitors or ARBs such as Enalapril (Vasotec) & Lisinopril (Prinivil, Zenstril) are taken during pregnancy
What is fetal injury/death?
Abrupt withdrawal of Metoprolol (Lopressor, Toprol XL) is not advised in patients with these conditions
What are angina or heart disease?
Montelukast (Singular) has only this common warning as a contraindication
What is hypersensitivity?
Gemfibrozil (Lopid), used to treat hypertriglyceridemia and hypercholesterolemia, should not be used for patients with patients with hepatic impairment, severe renal dysfunction or this pre-existing disease
What is gallbladder disease?
Hypotension and brachycardia are overdose signs for Atenolol (Tenormin). One of these two drugs may given to reverse the effect
What is atropine or isoproterenol?
Warfarin (Coumadin) can cause this reaction, so regular monitoring of INR is required
What is major or fatal bleeding?
"Epidural or spinal hematomas may occur when used in patients receiving spinal anesthesia or lumbar punctures. This can result in long-term or permanent paralysis, frequent monitoring for neurological impairment is essential" is the Black Box warning for this drug
What is Heparin?
Patients with complete AV block, severe HF, blood dyscrasia and myasthenia gravis should not take Propranolol (Inderal, InnoPan XL), nor should patients with this condition due to constriction of smooth muscle of the airways
What is COPD or asthma?
Serious liver disease, unexplained persistent elevations of serum transaminases and prior hypertensives to the drug are contraindications of this antihyperlipidemic drug
What is Atorvastatin (Lipitor)?
Vitamin K administration is the overdose procedure for this prototype drug
What is Warfarin (Coumadin)?
Amiodarone (Cordarone, Pacerone) can cause pneumonia-like symptoms in the lungs and has prodysrhythmic action possibly causing bradycardia, cardiogenic sock or AV block, but only when taken in this form
What is orally?
Because effectiveness is dependent on metabolic activated by CYP 450 enzymes, poor metabolizers will exhibit less therapeutic effect and more adverse cardiovascular events when taking this anti-platelet drug
What is Clopidogrel (Plavix)?
"Patients with hyperkalemia and those who previously experienced angioedema caused by ACE inhibitory therapy" is a contraindication of this heart failure drug
What is Lisinopril (Prinivil, Zestril)?
This drug is contraindicated in those with severe bradycardia, AV heart block, cardiogenic shock or
decompensated HF
What is Atenolol (Tenormin)?
Clopidogrel (Plavix) requires this type of transfusion to prevent further hemorrhage during an overdose
What are platelet transfusions?
This prototype drug should be reserved for life-threatening dysrhythmias because of the ability to produce new dysrhythmias or worsen existing ones
What is Procainamide?
This prototype drug is found to cause tumors in animals in clinical studies thus should only be used
in specified indications
What is Spironolactone (Aldactone)?
Patients with complete AV block, severe HF, blood dyscrasia and myasthenia gravis are contraindications of this prototype drug
What is Procainamide?
"Patients with anuria, significant impaired renal function or hyperkalemia should not take this. Also avoid during pregnancy and lactation" are the contraindications of this prototype drug
What is Spironolactone (Aldactone)?
Vasopressors for hypotension, atropine or isoproterenol with bradycardia, and IV glucagon for cardiac depression are all overdose treatments for this drug
What is Propranolol (Inderal, InnoPan XL)?
"Potent diuretic that if given in excess can lead to profound diuresis with water and electrolyte depletion. Careful medical supervision needed" is the warning for this prototype drug
What is Furosemide (Lasix)?
Abrupt withdrawal should be avoided in those with ischemic heart disease, instead gradual 1-2 discontinuation with reinstitution if angina symptoms worsen are the recommendations for this prototype drug
What is Atenolol (Tenormin)?
These are the 4 contraindications of the prototype drug Furosemide (Lasix)
What are hypersensitivity to furosemide or sulfonamides, anuria, hepatic coma and severe fluid or electrolyte depletion?
Cholestyramine (Questran) is contraindicated in patients with this kind of obstruction
What is total biliary obstruction?
A Sodium Chloride (NaCl) overdose is treated with diuretics to reduce these two types of edema, caused by fluid accumulation with excess sodium
What is pulmonary or peripheral edema?