A/B adrenergic
The two brand names of Tetrahydrozoline
What is Tyzine & Visine?
Timoptic is what generic drug?
Timilol
Name any 2 direct acting Cholinergics
acetylcholine - Miochol-E
bethanechol - Urecholine
carbachol - Isopto carbachol
pilocarpine - Isopto carpine
Give a combination of up to
1 primary action
and
2 Indications
for Anticholinergic Drugs
Primary actions
-Decrease vagus nerve activity (increasing HR)
-inhibit respiratory tract secretions/bronchoconstrictions
-decrease motility of GI
Indications/Uses
-bradycardia
-Perioperative inhibition of secretion
-COPD
-Asthma
_IBS
What 3 receptors are involved in the PSNS?
Nicotinic
Nicotinic Muscle
Muscarinic
Why are selective beta blockers more desired
Blocking bronchodilation has no therapeutic benefit
The only irreversible AChE inhibitor (Indirect acting cholinergic)
echothiophate - Phospholine
What drug is used to reactivate Acetylcholinesterase?
pralidoxime - 2 PAM
What is Cholinergic Toxicity?
PSNS overstimulation
-N/V, Diahorhey, diaphoresis, blurry vision, tremors, bradycardia, bronchoconstriction, hypotension
-excessive stimulation of muscarinic receptors of smooth muscles
-paralysis of skeletal muscles (due to Nm receptors)
Beta1, Beta 2
Name 4 medications that are used for HTN. Double points if you can name both the brand and the generic names for each correctly.
doxazosin - Cardura (AB)
prazosin - Minipress (AB)
terazosin - Hytrin (AB)
Carvedilol (NSBB)
propanolol - Inderal (NSBB)
timilol - Blocadren, Timoptic (NSBB)
atenolol - Tenormin (SB1B)
Bisprolol (SB1B)
Metoprolol - Lopresor (SB1B)
These 3 Indirect acting Cholinergics (Reversible AChE inhibitors) treat Alzheimers
Galantamine - Reminyl
donepezil - Aricept
rivastigmine - Exelon
Explain the difference between peripherally acting and centrally acting muscle relaxants
Peripheral: inhibits NM function at NMJ or within muscle fibers
Central: inhibits at spinal cord
sludge stands for
Salivation
Lacrimation
urination
diarrhea
GI upset
emesis
Name two of the three Beta 2 specific agonists
Salbutamol - ventolin
terbutaline - Brethine
salmeterol - Serevent
Name 3 AB blockers used for BPH
Try to include both names
doxazosin - Cardura
silodosin - Rapaflo
tamsulosin -Flomax
terazosin - Hytrin
What drug is used to treat Anticholinergic Toxicity
physostigmine
Why is succinylcholine special?
It is the only depolarizing peripheral relaxant (creates twitching before relaxing)
can cause malignant hypothermia
Epi stimulates this receptor, however NE does not
Beta 2
fun fact: beta 1 leads to renin release
Name the 3 doses of Dopamine and their effects
Low dose: 0.5-2.0 mcg/kg/min: vasodilation in renal and mesenteric, increased renal flow Moderate dose: 2.0-10.0 mcg/kg/min stimulate cardiac beta 1, increase contracticilty and CO High dose: >10.0mcg/kg/min: stimulate alpha receptor, vasoconstriction = increased BP
This NSBB drug passes the BBB leading to CNS depression and seizure. It is used to treat HTN, Arrhythmia, Angina
propanolol - Inderal
Myasthenia Gravis
-autoimmune response attacks Nm receptors
Reversible AChE inhibitors are used to increase ACh levels to compensate
Competition. Take 3 minutes. Write out as many peripherally and centrally acting relaxants as you can
Whoever has the most wins
You are the primary for a call of a young paramedic attacked by a rabid french cat with a knife. The only known medication (antimontrealcattin) comes in a supply of 8mg/ml. You have to administer 1mg/kg, and your pt is 79.2 lbs.
How many ml will you give?
4.5ml
Your patient's only side effect is an obnoxious English accent. Unfortunately the prognosis is poor.