Pharmacology

Adrenergic Drugs

100

The primary vasoactive drug used in ACLS protocol. Acts on both alpha and beta receptors innervated by the SNS. 

epinephrine or Adrenalin

200

Stimulates alpha adrenergic receptors, and beta1 receptors, with not beta2 stimulation. Treats hypotension and shock. Continuous infusion.

norepinephrine or Levophed

300

Almost exclusively alpha adrenergic receptors, used for short treatment for bp and shock. SVT, nasal decongestant, topical ophthalmic drug

phenylephrine or Neo-Synephrine

400

beta1 selective vasoactive, positive inptropy, IV given continuous infusion. 

dobutamine or Dobutrex

500

potent alpha1 and beta1, low does dilate blood vessels, high doses improve cardiac output, highest doses cause vasoconstriction, have special receptors that can only respond to this

dopamine or Intropin

Adrenergic Blocking Drugs

100

Contraindications

Known drug allergy or PVD

200

Reduces peripheral resistance, treats HTN, used to diagnose pheochromocytoma, most commonly used for treating extravasation, contraindicated in MI and CAD

phentolamine or Regitine

300

alpha blocker used to treat BPH in males and kidney stones in females, contraindicated with ED meds like sildenafil

Tamsulosin or Flomax

400

Indications

HTN, BPH, Pheochromocytoma, Raynaud's, acrocyanosis, frostbites, extravasation

500

Assessment precautions 

Hx of COPD, hypotension, cardiac dysrhythmia, bradycardia, HF, may cause dry mouth (eat sugarless gum and drink water)

Cholinergic Drugs

100

Neurotransmitter and Receptors

Acetylcholine, Nicotinic and Muscarinic

200

Cholinergic Crisis Signs, Antidote, SLUDGE

Early: abdominal cramps, flushing, N/V, transient syncope, orthostatic hypotension

Late: Circulatory collapse, shock, cardiac arrest

Atropine

salivation, lacrimation, urination, defecation, GI cramps, emesis

300

direct acting, acute post Op urinary retention, or management of urinary retention w/neurogenic atony of bladder

bethanechol or Urecholine

400

cholinesterase inhibitor, used to treat moderate Alzheimer's, similar to (galantamine and rivastigmine) 

doneprzil or Aricept

500

used to diagnosis myasthenia gravis and differentiate it from cholinergic crisis and the dugs used to treat MG

edrophonium or Tensilon

pyridostigmine or Mestinon and neostigmine

Cholinergic Blocking Drugs

100

Interactions

amantadine, antihistamines, phenothiazines, tricyclic antidepressants, dioxin

200

naturally occurring, used for bradycardia, ventricular asystole, antidote for anticholinesterase inhibitor toxicity, reduce pre Op salivation and GI secretions 

very similar to this drug as well but with less pazazzz

Atropine

glycopyrrolate or Rubinol

300

antispasmodic used for functional disturbances of GI motility like IBS

dicyclomine or Bentyl

400

antimuscarinic drug used for overactive bladder, antispasmodic for neurogenic bladder

oxybutynin or Ditropan

500

prevents motion sickness, can increase sedation when used with alcohol or CNS depressants

Scopolamine

Randoms

100

Antidote for atropine

physostigmine

200

Causes miosis

cholinergic drugs

300

alpha and beta receptors and their function

alpha=in the vessels vasoconstriction

beta1=located in heart increase CO

beta2=located in smooth muscle of bronchioles, arterioles, and visceral organs causing bronchodilation

400

inotropic chronotropic and dromotropic

contraction, heart rate, conduction through AV

500

Difference between PNS and SNS

SNS = mydriasis, reduce salivation, increased SV and HR, vasoconstriction, reduced GI, glycogenesis, inhibit bladder contraction

PNS = miosis, increase saliva, decreased HR, bronchoconstriction, GI increase, bladder constriction