ACE
What are ACE-I inhibitors for?
hypertension
What are DRIs for?
What are ARB's for?
hypertension
What are CCB for?
hypertension
What are the ACE inhibitors?
-prils; catopril, lisinopril, enalapril, ramipril, enalaprilat
What is the name of the DRI's
Aliskiren
What are the meds for ARBs
Losartan and Valsartan
What is the MOA of CCB (both types)
inhibits Ca influx through L-type channels to prevent binding to calmodulin and induce the contraction
What is the MOA of ACE-I inhibitors
Blocks the conversion of angiotensin II from angiotensin I
What is the MOA of DRIs?
blocks renin receptor
what is the MOA of ARBs
block binding of angiotensin II to the receptor (AT1R)
Which CCB only prevents binding of Ca in smooth muscle
-ipines; nifedipine & amlodipine
What are the contradictions of ACE-I inhibitors
pregnancy and bilateral renal artery stenosis
What are the adverse effects of DRI's?
hyperkalemia
teratogenesis
What are the contraindications of ARBs
pregnancy
bilateral renal artery stenosis
What happens if you give ACE-I / ARB to patient with bilateral renal artery stenosis?
prevents auto regulation of GFR
diabetic nephropathy
heart failure
heart attack (MI)
What is(are) the contradiction(s) of DRIs?
pregnancy
what are the adverse affects of ARBs
low aldosterone secretion -> hyperkalemia
low vascular tone -> hypotension
loss of efferent constriction -> low GFR
*if patient develops dry dough with ACE-I, switch to ARB
What are the adverse affects of ACE-I inhibitors?
lower aldosterone secretion -> hyperkalemia
low vascular tone -> hypotension
increase Bradykinin -> angioedema (swollen tongue & lips), dry cough, hypotension
loss of efferent constriction -> low GFR (stop diuretic first)