Adverse Effects
This cytotoxic antibiotic is classically associated with pulmonary toxicity and fibrosis
What is Bleomycin
Cancer cells treated with this chemotherapy agent show increased tubulin polymerization due to microtubule stabilization
What is Paclitaxel
This protein is impacted by a drug that may cause acneiform rash (a marker of effectiveness)
What is Epidermal Growth Factor (Osimertinib)
This promiscuous third generation BCR-ABL inhibitor has warnings for cardiac toxicity
What is Ponatinib
This residue is often found in kinase ATP binding domains and commonly mutates in cancer cells
What is Threonine
Dose-limiting nephrotoxicity and ototoxicity are classic adverse effects of this chemotherapy agent
What is Cisplatin
This chemotherapy drug inhibits topoisomerase I, leading to DNA strand breaks.
What is Irinotecan
This fusion event leads to a constitutively active kinase and has a targeted therapy
What is BCR-ABL (Imatinib)
This drug is given after a high dose of antifolate drug to rescue normal bone marrow from damage
What is leucovorin
Mutations in this oncogene predict resistance to EGFR inhibitors like cetuximab
What is KRAS
This cytotoxic drug is associated with cardiotoxicity due to free radical formation
What is Doxorubicin
By forming a covalent complex with thymidylate synthase and folate cofactors, this drug prevents dTMP synthesis
What is 5-fluorouracil
Methotrexate treats cancer and autoimmune disease by inhibiting this folate-cycle enzyme, reducing thymidine and purine synthesis.
What is dihydrofolate reductase
This drug is considered the best in mutant EGFR treatment
Osimertinib
When there is a mutation of residue 315 from threonine to isoleucine this drug is indicated
What is Ponatinib
This chemotherapy drug is associated with emergent hemorrhagic cystitis due to the toxic metabolite acrolein
What is Cyclophosphamide
This monoclonal antibody targets the extracellular domain of HER2, a receptor overexpressed in some breast and gastric cancers.
What is Herceptin (Trastuzumab)
Etoposide inhibits this target causing double-strand DNA breaks and apoptosis.
What is topoisomerase II
Unlike other antimetabolites, this drug alters the deoxyribose sugar of DNA, causing chain termination
What is Gemcitabine
While Erlotinib is the typical treatment for EGFR mutated cancers if the T790M mutation is present this drug is indicated
What is Osimertinib
This antimetabolite chemotherapy may cause cerebellar ataxia
What is Cytosine Arabinoside
Cetuximab inhibits EGF signaling through this mechanism.
What is binding the extracellular domain
Sotorasib was the first FDA-approved drug to target this previously “undruggable” oncogene in cancer.
What is KRAS
This selective estrogen receptor modulator (SERM) binds estrogen receptors, blocking estrogen-driven proliferation in ER-positive breast cancer.
What is Tamoxifen
This drug is only effective with a wild type KRAS in colorectal cancer
What is cetuximab