Side Effects Showdown
Mechanism Mayhem
Nursing Implications
Black Box Breakdown
Prototype Parade
Final Jeopardy
100

What class of drugs can cause nephrotoxicity and ototoxicity and accumulates in the kidney and inner ear?

What are aminoglycosides?

100

This diuretic works in the ascending loop of Henle to inhibit sodium and chloride reabsorption.

What is furosemide?

100

What should a nurse monitor before administering gentamicin?

What are peak and trough levels?

100

This antibiotic class has a warning for tendonitis and tendon rupture.

What are fluoroquinolones?

100

Prototype of aminoglycosides

What is gentamicin?

200

Which opioid side effect is the primary concern due to its potentially fatal consequences?

What is respiratory depression?

200

This drug works by binding to bacterial penicillin-binding proteins and inhibiting cell wall synthesis.

What is penicillin?

200

When administering morphine, what vital sign is the most critical to monitor?

What is respiratory rate?

200

IV administration of this drug can result in cardiopulmonary arrest.

What is Penicillin G?

200

Prototype of beta-lactam penicillins

What is ampicillin?

300

This class of drugs may cause hyperglycemia, fluid retention, and Cushingoid features with long-term use.

What are corticosteroids?

300

This opioid antagonist binds to mu receptors to reverse the effects of opioids.

What is naloxone?

300

Patients on spironolactone should be educated to avoid foods high in this electrolyte.

What is potassium?

300

Chronic use of this diuretic showed tumor development in rats.

What is spironolactone?

300

Prototype of loop diuretics

What is furosemide?

300

A patient with a history of chronic heart failure and a recent diagnosis of acute pyelonephritis is prescribed both furosemide and gentamicin. After 3 days of therapy, they develop tinnitus, increased BUN and creatinine levels, and dizziness upon standing.

Identify the most likely cause of these symptoms and explain the pharmacologic interaction at play.

What is aminoglycoside-induced ototoxicity and nephrotoxicity potentiated by loop diuretic use?

Gentamicin can cause both nephrotoxicity and ototoxicity. Furosemide, a loop diuretic, increases this risk due to its own ototoxic potential and its effects on renal perfusion. The combination requires close monitoring of serum drug levels, kidney function, and auditory symptoms.

400

What is the most concerning adverse effect of hydrochlorothiazide in patients with hepatic impairment?

What is hypokalemic and hypochloremic alkalosis?

400

Which corticosteroid alters gene transcription to suppress inflammation and immune response?

What is prednisone?

400

What dietary supplement increases the risk of photosensitivity in patients on ciprofloxacin?

What is St. John’s Wort?

400

Which opioid carries a black box warning for neonatal abstinence syndrome?

What is morphine sulfate?

400

Prototype of opioid antagonists

What is naloxone?

500

Which antimicrobial drug can cause tendon rupture, peripheral neuropathy, and QT prolongation?

What are fluoroquinolones?

500

This pain reliever acts on the hypothalamus to reduce fever but has no anti-inflammatory effects.

What is acetaminophen?

500

What patient teaching is important when giving oral cephalosporins?

Take with food to minimize GI upset.

500

This corticosteroid-related condition requires stress dosing during surgery.

What is adrenal insufficiency?

500

Prototype of corticosteroids

What is prednisone?