Kooky Pharmacokinetics
Dastardly Pharmacodynamics
Genius Pharmacogenomics
EN-give me the TEA!
Eye-ay-ay!
100
This is the point at which the rate of drug administration equals rate of drug elimination
Steady State
100
Ketamine is an example of a drug that has a very narrow...?
Therapeutic index
100
Pharmacogenetics allows for tailored drug dosing and choice based on an individuals genetic makeup. This is known as what approach in medicine
Personalized Medicine
100
These are the two routes in which allergen immunotherapy can be administered
SCIT and SLIT
100
Beulah is a nasty girl, and reuses her dirty contacts all the time! She most likely has an infection from this organism
BONUS 100 Points:
Name one medication that would treat an infection of this type
Pseudomonas
BONUS:
Neomycin
Gentamycin
Tobramycin
200
Drugs that are administered via an enteral route generally have decreased bioavailability due to this phenomenon
First-Pass Effect
200
Which drug has a higher POTENCY and why?
Drug A. It is able to reach the peak effect at a smaller dose than drug B.
200
Wilhelmina has multiple copies of the CYP2D6 gene, causing her to rapidly metabolize drugs. She would be classified as this metabolizer phenotype
Ultra Rapid Metabolizer
200
Concurrent use of Disulfiram should not occur with this expectorant or this antitussive
Guanfenesin and Dextromethorphan
200
This antibiotic is given to all newborns to prevent a gonococcal infection from passage through the vaginal canal
BONUS 100 Points:
Name the class that this drug belongs to
Erythromycin
BONUS:
Macrolide
300
Drugs must be lipophilic or have specific transport mechanisms in order to cross into this highly-selective part of the body
BONUS 100 points:
Name one drug that can pass through
Blood Brain Barrier
BONUS:
any 1st gen antihistamine
NSAIDS
Opiods + more!
300
Drugs and the receptors they bind to utilize these special molecules to relay, amplify, and regulate signals to produce a response in the body
Second Messengers
300
Having a polymorphism in CYP2C9 would cause decreased metabolism and possibly increased toxicity with the use of what drugs?(name at least one)
Warfarin, phenytoin, antidiabetic sulfonylurea +more!
300
Do not prescribe any of these medications with a ruptured TM, as they can cause ototoxicity with prolonged use!
BONUS 100 Points:
Nme what condition you could use these drugs for
Neomycin
Polymyxin B
Hydrocortisone
BONUS: AOE
300
Oswald is very proud of his beautiful blue eyes, but he was recently diagnosed with glaucoma and prescribed a prostaglandin analog to treat it. This common side effect of the drug, may shock Oswald when he first notices.
Iris pigmentation
400
This phase of metabolism attaches another molecule to the drug increasing its water solubility
BONUS 100 points:
Name one group that is commonly added during this phase
Phase II (Conjugation)
BONUS:
sulfate
acetyl
glucuronic acid
400
Naloxone is a life saving rescue drug for opioid overdose. It works by forcibly removing the opioid from its receptor in the brain, and blocking it from re-binding. This is an example of what kind of drug receptor interaction?
Competitive Antagonist
400
Increased toxicity from pyrimidine cancer chemotherapeudic agents can be caused by a polymorphism in this enzyme
Dihydropyrimidine Dehydrogenase(DPD)
400
Decongestants work via this mechanism of action to treat nasal congestion
sympathomimetic; acts on adrenergic receptors in local nasal mucosa to cause vasoconstriction which in turn improves ventilation
400
DAILY DOUBLE :DDD
Drugs used to treat Open Angle Glaucoma work by reducing IOP in one of these two ways
Increasing outflow of aqueous humor or Decreasing aqueous humor production
500
Michelle and Barack take the same drug, but Barack is able to absorb it faster. This is due to what anatomical and physiological difference between men and women?
Males have increased rate of gut motility and increased surface area in small intensine
500
Aunt Betsey is addicted to her Afrin. She used it once every hour for three days, and said it stopped working on the fourth day. Her doctor said she is having this type of reaction
BONUS 100 points:
what is the generic name for Afrin?
Tachyphylaxis
BONUS: oxymetazoline
500
Terrence has polymorphisms in the alleles coding for Human Leukocyte Antigen(HLA). He knows to avoid sulfa antibiotics, as they can cause this severe immunologic response
Stevens-Johnson Syndrome
500
Wadsworth went swimming in a rural mexican river system, and was diagnosed with severe otomycosis. He was prescribed this drug to treat the infection
Clotrimazole(Lotrimin Otic)
500
Guo is of Han Chinese descent, meaning he is predisposed to adverse reactions from drugs in this class
Carbonic Anhydrase Inhibitors