Pharmacologic Principles
Reduction in drug bioavailability due to metabolism in liver
First pass effect
Do not stop this drug abruptly
Prednisone
Avoid this drug in children under 8 years because it can cause permanent discoloration of teeth
Doxycycline
The antidote to this drug is vitamin K
Warfarin
This drug interacts with iodine contrast
Metformin
Airlock and Z track technique are used for this
Intramuscular injection
This can decrease when taking prednisone
Potassium
Monitor for signs of Steven-Johnson's syndrome when taking this antibiotic
Sulfa/trimethoprim
This drug can cause a non-productive cough and hyperkalemia
Enalapril
This type of insulin can be combined with intermediate acting insulin
Regular insulin/short acting insulin
5 rights of med administration
Right patient
Right drug
Right dose
Right time
Right route
Use this drug with caution in alcoholics and those with liver dysfunction
Ibuprofen and acetaminophen
This drug is used mainly on gram positive infections
Amoxicillin
The therapeutic index for digoxin
0.5-2 ng/mL
This insulin can be given IV bolus
Regular insulin/short acting insulin
inactive drug dosage form that is converted to an active metabolite by various biochemical reactions once it is inside the body
Pro drug
The prototype drug for all opioids
Morphine sulfate
Milk, antacids, and iron salts can decrease the absorption of:
Doxycycline and levofloxacin
Before giving metoprolol assess these two things
Blood pressure and apical pulse
This drug cannot be given to someone who's creatinine clearance is under 30
Metformin
Also referred to as biotransformation
Metabolism
Symptoms of acetaminophen poisoning
Rapid/weak pulse, dyspnea, cold/clammy extremities
This drug can potentiate hypoglycemic effects in diabetic patients
Sulfa/trimethoprim
This drug should not be given with bran, beta blockers, or calcium channel blockers. An adverse effect is halo vision
Digoxin
The onset of action for insulin glargine
1-2 hours