Farxiga iCVA
What tab in the iCVA can you find the extrapolation data?
-Urgency
What years where the guidelines updated for KDIGO, ACC HFrEF, ACC HFpEF, AHA/ACC/HFSA and ADA?
2024
2024
2023
2022
2025
What are AstraZenca's 5 values and behaviors?
-We follow the science
-We put patients first
-We play to win
-We do the right thing
-We are entrepreneurial
How much sodium does Lokelma contain in each 5g dose?
Each 5 g dose of LOKELMA contains approximately 400 mg of sodium, but the extent of absorption by the patient is unknown.
Where can you find study 1 information in the iCVA?
Efficacy - reductions at 1 hour
Where can you find the guidelines for the HFpEF patient in the iCVA?
- Guidelines, click CV, Click HFpEF.
What was the Relative Risk Reduction for Dapa - HF, Deliver and Dapa CKD?
26%
18%
39%
What year was AstraZeneca formed?
-1999 merger of Astra AB & Zeneca Group
What is the dose for Lokelma?
Recommended starting dose is 10 g administered three times a day for up to 48 hours.
• For maintenance treatment, recommended dose is 10 g once daily. Adjust dose at one-week intervals as needed (by 5 g daily) to obtain desired serum potassium target range.
• Recommended starting dose is 5 g once daily on non-dialysis days.
Where can you find the page that compares Lokelma, SPS & Veltassa on the Card & Neph iCVA?
Efficacy - product information
Safety - product information
Where can you find the Dapa/CKD primary and secondary endpoint results in the iCVA?
Efficacy, kidney, dapa-ckd pop-out
What was the relative risk reduction and absolute risk reduction for patients in the Dapa-CKD primary composite subgroup of HF?
42%
8.7%
Where is AstraZeneca's HQ? And Approximately how many employees?
Cambridge, England and over 80,000 employees
What is the MOA for Lokelma?
LOKELMA (sodium zirconium cyclosilicate) is a non-absorbed zirconium silicate that preferentially captures potassium in exchange for hydrogen and sodium.
Where can you find the guidelines on the Cards and Neph iCVA?
Summary
RAASi - 2024 KDIGO guideline
Where can you find baseline characteristics for the Dapa-HF study in the iCVA?
Additional information, Dapa-HF Study design
What is Farxiga's drop in FPG in the monotherapy trail for the 10mg & 5mg dose?
-28.8
-24.2
Placebo was -4.1 for reference. With Met (-60.4 on 10 mg dose)
How many projects are in our pipeline?
194
Reconstitution and Administration of Lokelma?
In general, other oral medications should be administered at least 2 hours before or 2 hours after LOKELMA.
Instruct patients to empty the entire contents of the packet(s) into a drinking glass containing approximately 3 tablespoons of water or more if desired. Stir well and drink immediately. If powder remains in the drinking glass, add water, stir and drink immediately. Repeat until no powder remains to ensure the entire dose is taken.
Where can you find the RAASi modification data in the iCVA?
Burden - RAASi Modification
Where can you find Farxiga dosing in the iCVA?
Safety - flip pooled safety
What is the absolute oral bioavailability of dapagliflozin following the administration of a 10mg dose?
78%
How many trees has AstraZeneca planed since 2020?
>40 Million trees
What temperature does Lokelma need to be stored at?
Store LOKELMA at 15°C-30°C (59°F-86°F).
Where can you find the MOA for Lokelma in the iCVA?
6 dots - video - MOA - open resource and play