Alcohol
Some heavy drinkers can develop problems to this organ of the body because alcohol weakens the muscles in and around this organ.
The Heart
Also, heavy drinking can constrict blood vessels causing high blood pressure. Other possible consequences are irregular or fast heartbeats, heart disease, and increased risk for stroke.
This activity can lead to loss of sense of smell, nosebleeds, problems with swallowing, hoarseness, and overall irritation of the nasal septum.
Snorting cocaine
Longer periods of snorting can cut off the blood flow in the nostrils and can cause membranes to die, resulting in a hole in the septum. The worst-case scenario is collapse of the entire nose.
Cigarette manufacturers add up to 600 of these to tobacco products such as cigarettes and "dip"
Chemicals
There are approximately 600 ingredients in cigarettes. When burned, cigarettes create more than 7,000 chemicals. At least 69 of these chemicals are known to cause cancer, and many are toxic.
Heavy drinking may "speed up" normal aging or cause premature aging of this organ.
The Brain
Research shows that shrinkage of the frontal lobes increases with both moderate and heavy drinking. This is related to causing intellectual impairment and can affect learning and memory.
The use of this substance can lead to psychotic symptoms (delusions, hallucinations, paranoia) that can persist for months or even years after use has ceased.
Meth (methamphetamine)
This chemical can influence the cells and tissues in the body that help protect against disease.
The THC in marijuana
THC may suppress your immune system making you more vulnerable to disease and infection. Research shows that when you use marijuana, your system increases its output of immune suppressor cells that suppress, or lower, your typical immune function.
Long-term heavy drinking increases the risk of developing several types of cancer because alcohol weakens this in the body.
The immune system
With a weakened immune system the body's ability to fight diseases and infections is greatly reduced.
Smoking these substances cause lung damage and increase the risk of cancer to the lungs, mouth, esophagus, and pancreas.
Tabaco & Marijuana
This organ is responsible for removing alcohol and other harmful substances from the body. Drinking more alcohol than this organ can break down results in the buildup of fat in this organ.
The Liver
Heavy drinking can lead to conditions affecting the liver such as alcoholic hepatitis (inflammation of the liver) with symptoms of fever, yellowing of the skin, eyeballs, and urine (jaundice), and abdominal pain. Although this can be reversed, if drinking continues it can cause death.
THC changes how the part of your brain called the hippocampus processes information. It affects the brain's ability to form new ones
Memories
10 to 20% of heavy drinkers develop this disease.
Cirrhosis of the liver
This scarring of the liver prevents it from filtering waste from the body and can cause death. This condition is not reversible, although symptoms can be relived and liver functioning improved by quitting drinking.
No matter how you use it, it can cause immediate and long-term effects, such as changes in perception and increased heart rate. Over time, may cause chronic cough and other health issues.
Cannabis