General
Knowledge
Knowledge
In the Nexlizet Study 053, name the percentage of patients on a statin therapy
What is 65%
The inhibition of this by bempedoic acid causes upregulation of LDL-C receptors, which leads to increased clearance of LDL-C in the blood.
What is ATP citrate lyase
In the bempedoic acid package insert, lab tests did what upon discontinuation of treatment
What is return to baseline
Elevated uric acid levels can lead to this disease in the body
What is gout
This is what you should do at first sign of a tendon rupture
What is discontinue treatment
In the Nexlizet Study 053, this was the median LDL-C at baseline
What is 149.7
This type of treatment MOA involves the inhibition of HMG-CoA reductase and therefore reduces the conversion of HMG-CoA to mevalonate
What is a statin
What is 4 weeks of treatment
What is first four weeks of treament
In clinical trials, this is the percentage of patients treated with bempedoic acid that experienced a tendon rupture
What is 0.5%
In the Nexlizet Study 053, the exclusion criteria for patients enrolled in the study was the following:
What is patients on simvastatin 40 mg or higher, fibrates, niacin, bile acid sequestrants, ezetimibe and PCSK9 inhibitors.
This type of treatment MOA involves the sterol transporter Neimann-Pick C1 Like 1 (NPC1L1)
What is ezetimibe
What is hemoglobin and leukocytes
This is the transporter that bempedoic acid inhibits that may lead to increased blood uric acid levels
What is Renal Tubular Organic Anion transporter 2 (OAT2)
This is the timeline that you may see tendon rupture once initiating bempedoic acid.
What are weeks to months of starting?
In the bempedoic acid package insert, there are two drug interactions to be concerned with. Provide the names and how to avoid any potential interactions
What is simvastatin > 20 mg and pravastatin > 40 mg. Avoid use.
This product reduces elevated LDL-C through inhibition of cholesterol synthesis in the liver and absorption in the intestine.
What is Nexlizet
In the bempedoic acid package insert, some patients experienced increases in hepatic transaminases. IN most cases these elevations were...
What is transient and resolved or improved with continued therapy or after discontinuation of therapy
This is the percentage of patients treated with bempedoic acid that experienced gout in the package insert
What is 1.5%
These areas of the body are involved in the tendon rupture warning in the bempedoic acid package insert
What are rotator cuff, biceps tendon and Achilles tendon
Name the 5 drug interactions outlined in the Nexlizet package insert
What is Simvastatin (avoid >20 mg), pravastatin (avoid >40 mg), cyclosporin (monitor), fibrates (don't use except fenofibrate) and cholestyramine (administer Nexlizet either at least 2 hours before or at least 4 hours after bile acid sequestrants.)
This enzyme activates bempedoic acid in the liver to reduce the biosynthesis of cholesterol, upregulate LDL receptors and increase the clearance of LDL-c
What is ACSVL1
In the bempedoic acid package insert, patients on bempedoic acid saw increases in various lab tests. Name at least 3.
What is creatine and blood urea nitrogen, platelet counts, liver enzymes and creatine kinase
This is the percentage of patients treated with bempedoic acid vs placebo that had no prior history of gout that ended up with gout.
What is 1% bempedoic acid group vs 0.3% placebo
Tendon ruptures have been determined to occur more frequently in these patient situations
What are patients > 60 years of age, those taking a corticosteroid or flourquinolone, patients in renal failure and in patients with previous tendon ruptures