Open question
What echo virus Stand for?
Enteric cytopathic human orphan virus
What causes post polio syndrome?
Due to overtime degeneration of motor neurons.
Which of the following picornaviruses is most strongly associated with aseptic meningitis outbreaks?
A. Hepatitis A virus
B. Coxsackievirus B
C. Rhinovirus
D. Poliovirus
Coxsackie B viruses are a common cause of aseptic meningitis, along with echoviruses
Which structural feature is characteristic of all members of the Picornaviridae?
A. Enveloped virion
B. Segmented RNA genome
C. Positive-sense single-stranded RNA genome
D. Double-stranded DNA genome
Picornaviruses are non-enveloped, +ssRNA viruses with a single linear genome.
What is bulbor polio myelitis?
Rare case of polio causing paralysis of respiratory, muscles and require mechanical ventilation
Why virus causes flaccid paralysis specifically?
Because it affects lower motor neurons -loss of muscle tone.
Which receptor is used by polio virus to enter host cell?
a. Cd4
B. ACE2
c. CD155
d. ICAM-1
CD155
Which of the following picornaviruses is most associated with hand-foot-and-mouth disease?
A. Coxsackievirus A16
B. Poliovirus
C. Hepatitis A virus
D. Rhinovirus
Coxsackie A16
Complete classification of coxsackievirus A
Family: picornaviridae
Genus: enterovirus
Species: coxsackieviruses
type : A
Which vaccine is needed for intestinal immunity? Why.
Oral polio vaccine because it produce igA in gut.
Which enterovirus is most strongly associated with dilated cardiomyopathy following myocarditis?
A. Coxsackievirus A
B. Coxsackievirus B
C. Echovirus
D. Enterovirus 70
Coxsackie B viruses infect myocardium → myocarditis → chronic dilated cardiomyopathy.
Which enterovirus is most commonly associated with acute hemorrhagic conjunctivitis outbreaks?
A. Enterovirus 70
B. Poliovirus
C. Coxsackievirus A16
D. Echoviru
Enterovirus 70
What is disadvantage of opv vaccine and why?
Because it an cause vaccine associated paralytic poliomyelitis.
How you intrept the color test result?
Yellow colour means - wrong serotype
Red colour- correct serotype
A mutation disrupting the VP1 capsid protein of an enterovirus would most likely impair:
A. RNA replication
B. Ribosome binding
C. Host cell receptor attachment
D. Polyprotein translation
C. Host cell receptor attachment
Which of the following best explains CNS invasion in poliovirus infection?
A. Direct bloodstream spread only
B. Retrograde axonal transport
C. Lymphatic obstruction
D. Immune complex deposition
B. Retrograde axonal transport
If you are in area of pandamic pilomylitis which vaccine you preferre to use and why ?
Preferred vaccine is Sapin ( OPV), because it over GIT and Blood immunity and so prevent spreading of the disease, while salk vaccine only help with individual immunity.
Why poliovirus selectively damage the anterior horn of spinal cord?
It is a neurotropic virus . It attaches to CD155 which is a receptor of lower motor neurons which are mainly present in anterior horn of spinal cord.
A researcher isolates an RNA virus that acts directly as mRNA and produces a single large polyprotein. Which enzyme must the virus encode?
A. Reverse transcriptase
B. RNA-dependent RNA polymerase
C. DNA polymerase
D. Integrase
B. RNA-dependent RNA polymerase
Why are enteroviruses resistant to ether?
A. Presence of lipid envelope
B. Lack of capsid
C. Absence of lipid envelope
D. DNA genome stability
Absence of lipid envelope