Steroids Save Lives!
What are the two types of adrenal insufficiency?
What is Primary & Secondary
Thyroid storm is a complication of Hypo or Hyper-thyroidism?
What is Hyperthyroidism
Checking for this may help you confirm a diagnosis of DKA?
I can accept two answers
I just had neurosurgery and now these are my labs: SNa 120, U/O 2 ml/kg/hr , UNa 350, what do I have?
CSW
What is first line treatment for pheochromocytoma and why?
alpha blockade (typically phenoxybenzamine)
What part of the adrenal gland secretes adrenaline and noradrenaline?
What is The Adrenal Medulla
What are some signs/symptoms of thyroid storm?
what is hyperpyrexia, tachycardia, AMS,?
How can you differentiate between HHS and DKA?
I just had neurosurgery and these are my labs: SNa 120, UNa 20, U/O 0.5 ml/kg/hr; What do I have?
SIADH
I am a potent glucocorticoid but have zero mineralocorticoid activity?
dexamathasone
What part of the adrenal gland secretes corticosteroids?
What is The adrenal cortex
Name one therapy for thyrotoxicosis that prevents de novo thyroid hormone synthesis?
What is Thioamide (PTU or methimazole)
Neurologic sequelae of DKA?
Cerebral edema
I just had Neurosurgery, these are my symptoms/labs: SNa 145, U/O 6 ml/kg/hr, urine SG 1.005, what should you give me?
Vasopressin for DI
What lab values aid in differentiating a diagnosis of CAH vs pyloric stenosis (infant with vomiting and dehydration)?
CAH: hyponatremia, hyperkalemia, acidosis, (markedly elevated 17-hydroxyprogesterone)
Pyloric stenosis: Hypochloremic, hypokalemic metabolic alkalosis
CAH is a type of primary adrenal insufficiency due to... deficiency?
What is 21-hydroxylase deficiency (autosomal recessive, mutations of CYP21A2 gene)
Name a therapy utilized to inhibit release of preformed thyroid hormone?
what is Lugols Solution (or potassium iodine)
What are the proposed mechanisms for $300 answer ?
Cytotoxic injury, vasogenic processes, and osmotic shifts during DKA treatment
What is the "triphasic response" - please describe?
Vasopressin deficiency (polyuria) after pituitary injury- unregulated release of stored vasopressin from necrotic vasopressin secreting neurons (SIADH) - Depletion of vasopressin stores
What is Waterhouse Friderichsen Syndrome?
acute adrenal failure related to acute hemorrhagic necrosis of adrenal glands due to infection
Which induction agent is associated with inhibition of cortisol production and what enzyme does it inhibit?
what is Etomidate, and 11-Beta hydroxylase
What is the mechanism for the therapy in $300 category?
Inhibits thyroid peroxidase which converts iodide to iodine and incorporates it into tyrosine to create diiodotyrosine and monoiodotyrosine needed to produce T4 and T3. PTU also acts peripherally to inhibit conversion of T4 to T3.
what is the mechanism for ketoacid production?
triglycerides-FFA-Beta oxidation and acetyl Co-A-acetoacetate becomes acetone and betahydroxybuterate
What is the osmotic threshold for ADH release?
280-290 mosmol/kg
Name an autosomal dominant inherited disorder associated with b/l pheochromocytoma:
What is Von-Hippel Lindau Syndrome