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Test that can be prolonged in von Willebrand disease but normal in ITP.
What is PTT?
von Willebrand factor carries and stabilizes this clotting factor.
What is Factor VIII?
Autoimmune destruction of platelets mediated by anti-GPIIb/IIIa antibodies.
What is ITP?
6-year-old post-viral infection with petechiae, isolated thrombocytopenia, normal PT/PTT.
What is ITP
Platelet sequestration from splenomegaly can mimic thrombocytopenia.
What is hypersplenism?
Platelet count in TTP is typically…
What is low?
This is the central step in the coagulation cascade, converting prothrombin to thrombin.
What is activation of Factor X to Xa?
ADAMTS13 deficiency causing platelet-rich microthrombi.
Young woman with fever, neurologic changes, thrombocytopenia, and renal dysfunction.
What is TTP
Hemolytic anemia, thrombocytopenia, and renal failure in a child post-E. coli O157:H7 infection.
What is HUS?
Lab finding that differentiates ITP from TTP or DIC in terms of coagulation studies.
What is normal PT & PTT in ITP?
The vitamin essential for gamma-carboxylation of factors II, VII, IX, and X; It is also given to newborns supplementally
What is vitamin K?
Widespread microthrombi with consumption of platelets and coagulation factors in sepsis or trauma.
What is DIC?
Trauma patient with oozing from IV sites, prolonged PT/PTT, low fibrinogen, elevated D-dimer.
What is DIC?
Prolonged bleeding time with normal platelet count and coagulation studies, suggests this is a connective tissue disorder rather than a platelet defect.
What is Ehlers-Danlos syndrome?
Platelet count below 50,000
What is Thrombocytopenia
This test measures the extrinsic and common pathways, and is prolonged in vitamin K deficiency.
What is PT / INR?
Inherited defect in GPIb leading to defective platelet adhesion and giant platelets.
What is Bernard-Soulier syndrome?
Newborn with mucocutaneous bleeding, giant platelets, absent aggregation with ristocetin.
What is Bernard-Soulier syndrome?
Purpura and low platelets in a child with recent parvovirus B19 infection may mimic ITP, but is actually this bone marrow condition.
What is transient aplastic crisis?
Gold standard test to confirm Glanzmann thrombasthenia.
What is platelet aggregation study showing absent aggregation with all agonists except ristocetin?
In DIC, this coagulation factor is decreased along with platelets and elevated D-dimer.
What is fibrinogen?
Inherited defect in GPIIb/IIIa leading to impaired platelet aggregation.
What is Glanzmann thrombasthenia?
A neonate presents with severe intracranial hemorrhage, prolonged PT, prolonged PTT, undetectable Factor V levels, normal platelet count, and normal fibrinogen.
What is congenital Factor V deficiency?
The triad of thrombocytopenia, eczema, and recurrent infections is seen in this X-linked syndrome.
Wiskott-Aldrich syndrome?