Introduction
What was the primary objective of this study?
To assess the frequency of polymicrobial ABC infections and their association with mortality.
What is carbapenem?
A class of antibiotics that are used to treat serious infections that are resistant to other antibiotics.
Did you find the figures in this study helpful? If not how would you have done them better?
I agree! These figures are so so good it is amazing.
What was the observed association between polymicrobial infections and 28-day mortality?
Polymicrobial infections were associated with lower 28-day mortality suggesting a potential survival advantage.
What questions do you still have about this paper or topic?
Wooow! Such great questions!!! :)
What was the authors hypothesis for this study?
Polymicrobial infections would be associated with lower mortality rates compared to monomicrobial infections if the presence of ABC indicates colonization.
How was Polymicrobial Infections defined by the authors of the study?
“Involving multiple microbial species”
Figure 1: What was the origin of the majority of the infections?
Patients with hospital-acquired infections
How did the study's findings regarding polymicrobial infection rates compare between pulmonary and bloodstream infections?
Their results were similarly high in both infections, showing no significant difference between the two.
What was most interesting about this paper?
Wow very interesting...... that you found that interesting...
How many studies across how many countries were used for this case study?
80 studies from 23 countries.
What are confidence intervals?
A range around a measurement that conveys how precise it is.
Figure 2: What is a heterogeneity index?
Heterogeneity index is a statistical measure that indicates how much variation exists between different studies in a meta-anaylsis.
What implications do the findings have for clinical practice regarding the treatment of ABC infections?
Clinicians may need to consider the potential for lower mortality in polymicrobial infections and carefully assess the role of ABC as a colonizer versus a pathogen.
Did you like this paper? Why or why not?
This is the best paper of ALL TIME come on now everyone :(
Why is it difficult for researchers to differentiate between colonization and infection in this study?
They have similar mortality rates.
What is colonization?
Pathogens that are present on/in the host but does not cause illness.
Figure 3: What did figure 3 depict? How did it helps demonstrate the results of the study?
The figure depicted 28/30 day mortality, and showed monomicrobial to be more dangerous.
How does Acinetobacter baumannii’s role likely differ in polymicrobial infections vs monomicrobial infections?
Acinetobacter baumannii is a true infecting pathogen in polymicrobial infections, while it likely acts as a causative pathogen in monomicrobial infections
What directions would you take further research on this topic?
Wow that sounds like a great comp idea!!!
What is Acinetobacter baumannii-calcoaceticus complex? Can you give any examples of specific infections caused?
Group of gram-negative bacteria causing infections such as pnemonia, bloodstream infections, and wound infections.
What does GRADE stand for? What is it?
Grading of Recommendations Assessment, Devlopment, and Evalutation.
Method of assessing certainty in evidence and strength of recommentations in health care research.
Figure 4: What does this figure tell us about the findings?
This gives us the statistical difference between 28/30 day risk in polymicrobial infections and monomicrobial infections.
ABC mortality rate is observed to be lower than gram-negative but higher than gram-positive.
What would you have done differently for a study on Polymicrobial infections?
What a great answer! You are soooooo smart