Agents
1) Alpha2
2) Opioid
Antagonists work in what way:
they displace the agents from the receptor sites
When reversing alpha2-agonists, which 2 main side effects are we looking to reverse?
1) cardiovascular
2) sedative
True/False: reversal agents work on agents other than what they are labeled for
False
List the reversal agent for opioid agents:
Naloxone
True/False: antagonists are dose dependent
True
When using opioid antagonists - which agent is likely unaffected when causing respiratory depression?
Buprenorphine
Alpha2-antagonists reverse both the _____ and the _____ qualities of the agents use:
detrimental and beneficial
List the 3 reversal agents available (and their agents) available for apla2-agonists:
1) Yohimbine = Xylazine
2) tolazine = Xylazine
3) Atipamezole = Dexmedetomidine
Naloxone acts by binding to which receptors:
mu, kappa and sigma
Which receptor does buprenorphine bind to?
Mu
Unlike alpha2-antagonists; opioid antagonists are very useful when reversing ____ in emergencies:
overdoses
What is the antagonist that is used to reverse opioids used on wild animals such as etorphine:
Diprenorphine
Naloxone acts as quickly as: (minutes)
2 minutes
When using alpha2-antagonists, what is of concern when reversing patients?
rapid reversal - excitement and aggression
Alpha2-antagonist agents are dosed expressed using:
ratios: 10:1 (0.1mg/kg or 1/10th the antagonist dose)
List 2 reasons that antagonists are used:
1) to reverse undesirable side effects of an agent
2) a procedure is over
Naloxone has a duration of action of: (minutes)
30-60 minutes
What is the main concern when reversing any agent?
the reversal of the analgesic qualities
When using/administering opioid antagonists, what is the recommended method of dosing?
titrated based on admin time of agent