Protein misfolding
What's the monomer of a protein?
Amino acid
Mad Cow was found in what animal
Cow
Infectious 🦠
Ability to spread around.
Name one way Prion disease can spread 😷
contaminated surgical equipment, blood transfusion, infected meat
Weak bonds stabilizing protein shape
Hydrogen bonds
Name one type of protein misfolding disease
What is an amino acid
A molecule that contains a carbonyl group, carboxyl group, and an amino group,
(if you said any of the three you still get the point)
what are some ways scientist have tried to slow the progression of protein 🩺
Gene therapy
Congo Red
Trehalose
This type of protein speeds up chemical reactions in the body without being used up.
Enzyme
The quiet phase shows what symptoms
No symptoms
Scrapie's was found in what animal
Sheep
Neuron Cell Death
The permanent loss of nerve cell structure and function, occurs naturally during brain development or due to injury/disease.
This type of bond forms when amino acids link together to build a protein chain.
peptide bond
Which protein misfold disease is known for causing tremors.
Parkinson's disease
Why are rats most commonly used animal for scientific experiments?
1 of the 5 work
- easy to keep/house
-similarities in psychology
-fast life cycle
-understood genetics
PrP
Prion Protein
What analogy was used to describe what happens to the cells when proteins misfold
Origami analogy
This level of protein structure refers to the final 3D shape of a folded protein
quaternary structure
What are prions?
Abnormal proteins that clump in the brain.
In this fatal human brain disorder, misfolded proteins cause rapid dementia and a sponge-like appearance in brain tissue.
Creutzfeldt-Jakob disease? [Jacob disease is acceptable]
Particle
-physical nature of the agent,
-tiny piece of matter that makes up everything around us, like atoms or smaller parts of atoms.
What analogy was used to describe the symptoms of protein misfolding
Rain/thunder
When an egg white turns solid while cooking, this process is happening to its proteins
denaturation