General
Tolerance vs sensitization. Explain the types of tolerance. Drug action vs effect.
Decrease vs increase in response. Metabolic, cellular, learned. Mechanism vs observable effect
Agonist vs antagonist. Explain how each affects the 4 steps of neurotransmission.
Enhances vs decreases the function of a synapse. Agonist - enhances synthesis & storage, release, and action, but decreases inactivation. Antagonist - enhances inactivation, but decreases synthesis & storage, release, and action.
Substance dependence, substance abuse, substance addiction.
1. A state in which an organism functions normally only in the presence of a drug
2. Reliance on drug chronically and excessively
3. Compulsive drug seeking behavior despite negative consequences
Seven routes of administration. Explain the pros and cons of every route.
1. Oral
2. Topical
3. Inhalation
4. Rectal suppository
5. Intravenous
6. Intramuscular
7. Intracerebral
Explain the 5 groups of drugs, including the transmitter system, effect on behavior, and what they are used for.
1. Antianxiety drugs - GABAergic, relaxation, sedation.
2. Antipsychotic drugs - DA and 5-HT, delusions, schizophrenia.
3. Antidepressants - 5-HT, mood stabilization, depression.
4. Opioid Analgesics - opioidergic, pain relief.
5. Psychotropics - DA, stimulation.