Lithium MOA
Inhibit dopamine and glutamate and promotes GABA-mediated neurotransmision
Risperdal causes.....
lamotrigine
Lamictal
What three medications are used to treat EPS?
1. benztropine (Cogentin)
2. trihexyphenidyl (Artane)
3. diphenhydramine (Benadryl)
T/F - When a pt is on alzheimer medication c/o n/v/d you should discontinue the medicaiton.
FALSE. Titrate dose to reduce GI effects
Lithium USES
- mood swings
- mania
- antisuicidal
- neuroprotective
Medication adverse effect includes: weight loss and mental dulling
oxcarbazepine
What three Extrapyramidal symptoms are relieved by antiparkinson medication?
Dystonia, Akathisia, Parkinsonism
Taking donepezil (Aricept) and rivastigmine (Exelon) with concurrent NSAIDs use puts the patient at risk for what?
GI BLEED
What are the common side effects of Lithium?
nausea, fine tremors, increased thirst, polyuria, weight gain
What medication causes Stevens Johnson syndrome?
lamotrigine (Lamictal)
asenapine
Saphris
This medication is used to treat NMS by "Promoting dopamine"
bromocriptine (Parlodel)
Which medication is approved for moderate to severe stages of alzheimer?
memantine (Namenda)
Signs of lithium toxicity
confusion, blurred vision, diarrhea, tinnitus, coma, convulsion
Depakote therapeutic range and toxicity level
Therapeutic range :50-125
Toxic: >150
cariprazine
Vraylar
These two medications help with eye blinking and grimacing, striking tongue out, jerking hand and leg movements manifestations of a condition known as Tardive Dyskinesia.
valbenazine (Ingrezza)
deutetrabenazine (Austedo)
What past medical hx should you be aware of when administering Aricept and Exelon for the risk of causing bronchoconstriction?
Asthma and COPD
Lithium therapeutic range + Toxicity levels
Therapeutic: 0.6 - 1.2
MILD: 1.5 - 2
MODERATE: 2-3
SEVERE: >3
What two things does Tegretol cause and at what level do you D/C?
1. Agranulocytosis
2. aplastic anemia
3. ANC <1000
Caplyta
lumateperone
This medication inhibits calcium release from the sarcoplasmic reticulum helping symptoms of neuroleptic malignant syndrome like muscle rigidity.
dantrolene / Dantrium
What three medication subgroups are contraindicated with Aricept and Elexon for the risk of reducing therapeutic effects?
TCAs, FGAs, antihistamines