Psychopharmajeopardy

Antidepressants

100

What 2 antidepressants can cause withdrawal symptoms if a single dose is missed?

Paroxetine, venlafaxine

200

What dose does venlafaxine XR start to exhibit noradrenergic properties?

150mg

300

What is the most rationale antidepressant combination? a) TCA + MAOI b) SSRI + TCA c) SSRI + bupropion d) SSRI/SNRI + mirtazapine

SSRI + bupropion

400

Which TCA is gold standard for treatment of OCD?

Clomipramine

Antipsychotics

100

Aripiprazole is available as 2 formulations. What are they?

oral tablet & long-acting IM injection

200

What is the difference between Clopixol, Clopixol Acuphase & Clopixol Depot?

Formulation and duration of action of IM injection

300

What depot antipsychotic do we initiate with a loading dose?

Paliperidone palmitate (Invega Sustenna)

400

What 2 antipsychotics must be taken with meals to ensure complete absorption?

ziprasidone & lurasidone

Substance Use Disorders

100

Name 3 prescription drugs that have street value (excluding narcotics & benzos)

• Amphetamines/stimulants: Dexedrine (dextroamphetamine), Adderall (mixed salts), Ritalin/Concerta/Biphentin (methylphenidate), Vyvanse (lisdexamfetamine) • Dextromethorphan • Anticholinergics (trihexyphenidyl, benztropine, baclofen, quetiapine, dimenhydrinate) • Bupropion • Gabapentin • Zopiclone, zolpidem

200

Withdrawal from which 2 classes can be potentially life threatening? a) alcohol b) benzodiazepines c) opioids d) stimulants

alcohol & benzodiazepines

300

Name 1 prescription medication and 1 illicit substance that can cause drug-induce psychosis

Prescription medication: amphetamines, corticosteroids, dopamine (levodopa), dopamine agonists (ropinirole, pramipexole) Illicit substances: cannabis, cocaine, LSD

400

How many days of missed Suboxone doses can lapse before the dose has to be adjusted or re-titrated?

5 days

Adverse Effects of Psychotropics

100

Benztropine can be used for which of the following type(s) of EPS: a) Acute dystonia b) Tardive dyskinesia c) Akathisia

acute dystonia

200

State 3 differences in presentation between neuroleptic malignant syndrome and serotonin syndrome

medication history (pro-serotonergic drug vs dopamine antagonist), time to onset (< 12 hrs vs 1-3 days), pupils (mydriasis vs normal), bowel sounds (hyperactive vs normal/decreased), neuromuscular tone (increased in lower extremities vs “lead-pipe” rigidity in all muscle groups), reflexes (hyperreflexia vs bradyreflexia), mental status changes (agitation vs stupor)

300

There have been clozapine-related deaths in Canada due to which of the following side effects (pick 2)? a) agranulocytosis b) constipation c) myocarditis

constipation & myocarditis

400

Name 1 antidepressant that has NOT been associated with QT prolongation at therapeutic doses

duloxetine, bupropion, paroxetine

Anything Under the Sun

100

When should a lithium level be drawn? a) Peak b) 12 hour trough c) 24 hour trough

12 hour trough

200

List 3 non-psychiatry drugs that can contribute to serotonin syndrome

analgesics (meperidine, fentanyl, tramadol), antiemetic agents (ondansetron, metoclopramide), antimigraine drugs (sumatripan), linezolid, dextromethorphan, MDMA, St. John’s wort, ginseng

300

Name 1 difference between zopiclone and zolpidem

half-life

400

Aripiprazole can be used as monotherapy for treatment of depression. True or false?

False