Pharmacokinetics
These antipsychotics were the first drugs developed to treat psychosis. They are highly protein bound, very lipid soluble, and are highly concentrated in the brain.
Typical Antipsychotics like phenothiazines (Professional, 2024), (Rebar, et al., 2022, p.553)
Looking for a neurotransmitter and hormone that is blocked by antipsychotic drugs. Parkinson’s disease has too little, and schizophrenia has too much.
Dopamine (Rebar et al., 2022, p.556)
This class is the treatment of choice for ADHD.
Stimulants (Rebar et al., 2022, p. 559)
This antianxiety drug does not have a toxic additive effect with alcohol or other CNS depressants
Buspirone (Rebar et al., 2022, p.532)
Toxic side effects are confusion, ataxia, and seizures, just like the name of the song, a particular pop star that was rumored to have taken it.
Lithium (Rebar et al., 2022, p.550)
This mood stabilisers name derives from a Greek word that translates in English to “stone”. It is absorbed rapidly and completely and is excreted from the body UNCHANGED through the kidneys.
Lithium (LITHIUM: Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews, n.d.), (Rebar, et al., 2022, p.549)
Excessive catecholamine causes mania and too little causes depression. A combination of both results in bipolar disorder. Name the drug that regulates catecholamine release, also known as the name of a Nirvana song.
Lithium (Rebar et al., 2022, p.549)
With several therapeutic uses, as a sedative this subclass is used for preoperative sedation and anesthesia but can cause physical dependence.
Barbiturates (Rebar et al., 2022, p. 526-527)
Drugs that alter the P-450 enzyme system will alter the metabolism of what kind of antipsychotic
Atypical (Rebar et al., 2022, pg. 556)
This antipsychotic subclass has higher potential for serious neurologic effects including extrapyramidal symptoms and neuroleptic malignant syndrome.
Typical antipsychotics (Rebar et al., 2022, p. 555)
This antidepressant undergoes the first pass effect, has slow excretion rates, and long half-lives. Their long half-lives increase their risk of lethality if taken in excess.
Tricyclic antidepressants like amoxapine (Rebar, et al., 2022, p.543)
Antidepressants and mood stabilizing drugs like SSRIs affect ____ of serotonin and norepinephrine.
Reuptake (Rebar et al., 2022, p.534)
Primarily used to treat episodes of major depression, this subclass can also be used to prevent migraines and treat OCD and neuropathy.
TCAs (Rebar et al., 2022, p. 543-544)
What class should not be used within 14 days of discontinuing an MAOIS.
Stimulants (Rebar et al., 2022, p.559)
From liver issues, orthostatic hypotension, drowsiness, dizziness, headache and insomnia to GI issues, urine retention, impotence, dry mouth, and blurred vision; this class was initially intended as an antituberculosis drug.
MAOI (Rebar et al., 2022, p.541)
These drugs were the first antidepressants to be used. They are absorbed rapidly and completely through the GI tract, metabolized in the liver to its inactive form, and excreted mainly by the GI tract, and somewhat by the kidneys.
Monoamine Oxidase Inhibitors like MAO-A or MAO-B (Rebar, et al., 2022, p.539)
Known by the trade name Adderall, this class of psychotropic drug works by increasing levels of dopamine and norepinephrine.
Stimulants (Rebar et al., 2022, p.559)
As the first line of treatment for schizophrenia, this subclass can also be used for mania, bipolar disorder, and treatment resistant depression.
Atypical antipsychotics (Rebar et al., 2022, p. 556)
A decrease in salt can cause toxicity, and increased sodium intake may reduce the therapeutic effect of this drug.
Lithium (Rebar et al., 2022, p. 550)
What chemical class of drugs may you notice mental status changes, including unusual behavior, like eating or driving a car while sleeping
Nonbenzodiazepine drugs (Rebar et al., 2022, pg.528)
This antidepressant can be used to treat obsessive compulsive disorders and premenstrual dysphoric disorder. It is absorbed almost completely after oral administration, metabolised in the liver, and excreted in urine.
Selective Serotonin Reuptake Inhibitor like Sertraline (Rebar, et al., 2022, p.534-535)
This chemical class is believed to bind on or near the GABA receptors, enhancing the effect of GABA and allowing more chloride ions to flow into the postsynaptic neuron.
Benzodiazepines (Rebar et al., 2022, p.522)
This drug is used to treat generalized anxiety states, but with a slow onset of action is ineffective for quick relief.
Buspirone (Rebar et al., 2022, p. 532)
If you use me with acetylcholine-blocking drugs it can lead to paralytic ileus. HINT: antidepressant class
Tricyclic antidepressants (Rebar et al., 2022, p.545)
This Antidepressant causes decreased glucose concentration, Stevens Johnson's syndrome, and suicidal ideation. It is also known as Prozac and Sarafem. Watch out for SHIVERS when taking this drug.
Fluoxetine (Fluoxetine: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing - WebMD, n.d.) (Skidmore-Roth, 2024, p.571-573)